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@ARTICLE{Valk:877661,
      author       = {Valk, Sofie L. and Hoffstaedter, Felix and Camilleri, Julia
                      and Kochunov, Peter and Yeo, B. T. Thomas and Eickhoff,
                      Simon B.},
      title        = {{P}ersonality and local brain structure: their shared
                      genetic basis and reproducibility},
      journal      = {NeuroImage},
      volume       = {220},
      issn         = {1053-8119},
      address      = {Orlando, Fla.},
      publisher    = {Academic Press},
      reportid     = {FZJ-2020-02371},
      pages        = {117067 -},
      year         = {2020},
      note         = {AcknowledgementsWe would like to thank the various
                      contributors to the open access databases that our data was
                      downloaded from. Specifically; HCP data were provided by the
                      Human Connectome Project, Washington University, the
                      University of Minnesota, and Oxford University Consortium
                      (Principal Investigators: David Van Essen and Kamil
                      Ugurbil;1U54MH091657) funded by the 16 NIH Institutes and
                      Centers that support the NIH Blueprint for Neuroscience
                      Research; and by the McDonnell Center for Systems
                      Neuroscience at Washington University. GSP data were
                      provided by the Brain Genomics Superstruct Project of
                      Harvard University and the Massachusetts General Hospital,
                      (Principal Investigators: Randy Buckner, Joshua Roffman, and
                      Jordan Smoller), with support from the Center for Brain
                      Science Neuroinformatics Research Group, the Athinoula A.
                      Martinos Center for Biomedical Imaging, and the Center for
                      Human Genetic Research. 20 individual investigators at
                      Harvard and MGH generously contributed data to the overall
                      project.For enhanced NKI, we would like to thank the
                      principal support for the enhanced NKI-RS project is
                      provided by the NIMH BRAINS R01MH094639-01 (PI Milham).
                      Funding for key personnel was also provided in part by the
                      New York State Office of Mental Health and Research
                      Foundation for Mental Hygiene. Funding for the decompression
                      and augmentation of administrative and phenotypic protocols
                      provided by a grant from the Child Mind Institute
                      (1FDN2012-1). Additional personnel support provided by the
                      Center for the Developing Brain at the Child Mind Institute,
                      as well as NIMH R01MH081218, R01MH083246, and R21MH084126.
                      Project support also provided by the NKI Center for Advanced
                      Brain Imaging (CABI), the Brain Research Foundation
                      (Chicago, IL), and the Stavros Niarchos Foundation. Last, we
                      want to thank L.C.Valk for proofreading the manuscript.},
      abstract     = {Local cortical architecture is highly heritable and
                      distinct genes are associated with specific cortical
                      regions. Total surface area has been shown to be genetically
                      correlated with complex cognitive capacities, suggesting
                      cortical brain structure is a viable endophenotype linking
                      genes to behavior. However, to what extend local brain
                      structure has a genetic association with cognitive and
                      emotional functioning is incompletely understood. Here, we
                      study the genetic correlation between personality traits and
                      local cortical structure in a large-scale twin sample (Human
                      Connectome Project, n=1102, 22-37y) and we evaluated whether
                      observed associations reflect generalizable relationships
                      between personality and local brain structure two
                      independent age-matched samples (Brain Genomics
                      Superstructure Project: n=925, age=19-35y, enhanced Nathan
                      Kline Institute dataset: n=209, age: 19-39y). We found a
                      genetic overlap between personality traits and local
                      cortical structure in 10 of 18 observed phenotypic
                      associations in predominantly frontal cortices. However, we
                      only observed evidence in favor of replication for the
                      negative association between surface area in medial
                      prefrontal cortex and Neuroticism in both replication
                      samples. Quantitative functional decoding indicated this
                      region is implicated in emotional and socio-cognitive
                      functional processes. In sum, our observations suggest that
                      associations between local brain structure and personality
                      are, in part, under genetic control. However, associations
                      are weak and only the relation between frontal surface area
                      and Neuroticism was consistently observed across three
                      independent samples of young adults.},
      cin          = {INM-7},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-7-20090406},
      pnm          = {573 - Neuroimaging (POF3-573)},
      pid          = {G:(DE-HGF)POF3-573},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:32574809},
      UT           = {WOS:000579184700025},
      doi          = {10.1016/j.neuroimage.2020.117067},
      url          = {https://juser.fz-juelich.de/record/877661},
}