TY  - JOUR
AU  - Pennig, Lenhard
AU  - Thiele, Frank
AU  - Goertz, Lukas
AU  - Laukamp, Kai Roman
AU  - Perkuhn, Michael
AU  - Kabbasch, Christoph
AU  - Schlamann, Marc
AU  - Fink, Gereon Rudolf
AU  - Borggrefe, Jan
TI  - Comparison of Accuracy of Arrival-Time-Insensitive and Arrival-Time-Sensitive CTP Algorithms for Prediction of Infarct Tissue Volumes
JO  - Scientific reports
VL  - 10
IS  - 1
SN  - 2045-2322
CY  - [London]
PB  - Macmillan Publishers Limited, part of Springer Nature
M1  - FZJ-2020-02373
SP  - 9252
PY  - 2020
AB  - The purpose of this study was to compare the performance of arrival-time-insensitive (ATI) and arrival-time-sensitive (ATS) computed tomography perfusion (CTP) algorithms in Philips IntelliSpace Portal (v9, ISP) and to investigate optimal thresholds for ATI regarding the prediction of final infarct volume (FIV). Retrospective, single-center study with 54 patients (mean 67.0 ± 13.1 years, 68.5% male) who received Stroke-CT/CTP-imaging between 2010 and 2018 with occlusion of the middle cerebral artery in the M1-/proximal M2-segment or terminal internal carotid artery. FIV was determined on short-term follow-up imaging in two patient groups: A) not attempted or failed mechanical thrombectomy (MT) and B) successful MT. ATS (default settings) and ATI (full-range of threshold settings regarding FIV prediction) maps were coregistered in 3D with FIV using voxel-wise overlap measurement. Based on an average imaging follow-up of 2.6 ± 2.1 days, the estimation regarding penumbra (group A, ATI: r = 0.63/0.69, ATS: r = 0.64) and infarct core (group B, ATI: r = 0.60/0.68, ATS: r = 0.63) was slightly higher in ATI but the effect was not significant (p > 0.05). Regarding ATI, Tmax (AUC 0.9) was the best estimator of the penumbra (group A), CBF relative to the contralateral hemisphere (AUC 0.80) showed the best estimation of the infarct core (group B). There was a broad range of thresholds of optimal ATI settings in both groups. Prediction of FIV with ATI was slightly better compared to ATS. However, this difference was not significant. Since ATI showed a broad range of optimal thresholds, exact thresholds regarding the ATI algorithm should be evaluated in further prospective, clinical studies.
LB  - PUB:(DE-HGF)16
C6  - pmid:32518270
UR  - <Go to ISI:>//WOS:000543955500001
DO  - DOI:10.1038/s41598-020-66041-6
UR  - https://juser.fz-juelich.de/record/877663
ER  -