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@ARTICLE{Pennig:877663,
      author       = {Pennig, Lenhard and Thiele, Frank and Goertz, Lukas and
                      Laukamp, Kai Roman and Perkuhn, Michael and Kabbasch,
                      Christoph and Schlamann, Marc and Fink, Gereon Rudolf and
                      Borggrefe, Jan},
      title        = {{C}omparison of {A}ccuracy of
                      {A}rrival-{T}ime-{I}nsensitive and
                      {A}rrival-{T}ime-{S}ensitive {CTP} {A}lgorithms for
                      {P}rediction of {I}nfarct {T}issue {V}olumes},
      journal      = {Scientific reports},
      volume       = {10},
      number       = {1},
      issn         = {2045-2322},
      address      = {[London]},
      publisher    = {Macmillan Publishers Limited, part of Springer Nature},
      reportid     = {FZJ-2020-02373},
      pages        = {9252},
      year         = {2020},
      abstract     = {The purpose of this study was to compare the performance of
                      arrival-time-insensitive (ATI) and arrival-time-sensitive
                      (ATS) computed tomography perfusion (CTP) algorithms in
                      Philips IntelliSpace Portal (v9, ISP) and to investigate
                      optimal thresholds for ATI regarding the prediction of final
                      infarct volume (FIV). Retrospective, single-center study
                      with 54 patients (mean 67.0 ± 13.1 years, $68.5\%$
                      male) who received Stroke-CT/CTP-imaging between 2010 and
                      2018 with occlusion of the middle cerebral artery in the
                      M1-/proximal M2-segment or terminal internal carotid artery.
                      FIV was determined on short-term follow-up imaging in two
                      patient groups: A) not attempted or failed mechanical
                      thrombectomy (MT) and B) successful MT. ATS (default
                      settings) and ATI (full-range of threshold settings
                      regarding FIV prediction) maps were coregistered in 3D with
                      FIV using voxel-wise overlap measurement. Based on an
                      average imaging follow-up of 2.6 ± 2.1 days, the
                      estimation regarding penumbra (group A, ATI:
                      r = 0.63/0.69, ATS: r = 0.64) and infarct core
                      (group B, ATI: r = 0.60/0.68, ATS: r = 0.63) was
                      slightly higher in ATI but the effect was not significant
                      (p > 0.05). Regarding ATI, Tmax (AUC 0.9) was the best
                      estimator of the penumbra (group A), CBF relative to the
                      contralateral hemisphere (AUC 0.80) showed the best
                      estimation of the infarct core (group B). There was a broad
                      range of thresholds of optimal ATI settings in both groups.
                      Prediction of FIV with ATI was slightly better compared to
                      ATS. However, this difference was not significant. Since ATI
                      showed a broad range of optimal thresholds, exact thresholds
                      regarding the ATI algorithm should be evaluated in further
                      prospective, clinical studies.},
      cin          = {INM-3},
      ddc          = {600},
      cid          = {I:(DE-Juel1)INM-3-20090406},
      pnm          = {572 - (Dys-)function and Plasticity (POF3-572)},
      pid          = {G:(DE-HGF)POF3-572},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:32518270},
      UT           = {WOS:000543955500001},
      doi          = {10.1038/s41598-020-66041-6},
      url          = {https://juser.fz-juelich.de/record/877663},
}