000877688 001__ 877688
000877688 005__ 20210130005212.0
000877688 0247_ $$2doi$$a10.1093/chemse/bjaa041
000877688 0247_ $$2ISSN$$a0379-864X
000877688 0247_ $$2ISSN$$a1464-3553
000877688 0247_ $$2Handle$$a2128/25865
000877688 0247_ $$2altmetric$$aaltmetric:84532590
000877688 0247_ $$2pmid$$apmid:32564071
000877688 0247_ $$2WOS$$aWOS:000591530900014
000877688 037__ $$aFZJ-2020-02398
000877688 082__ $$a540
000877688 1001_ $$0P:(DE-HGF)0$$aParma, Valentina$$b0$$eCorresponding author
000877688 245__ $$aMore than smell – COVID-19 is associated with severe impairment of smell, taste, and chemesthesis
000877688 260__ $$aOxford$$bOxford Univ. Press$$c2020
000877688 3367_ $$2DRIVER$$aarticle
000877688 3367_ $$2DataCite$$aOutput Types/Journal article
000877688 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1602512485_1212
000877688 3367_ $$2BibTeX$$aARTICLE
000877688 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000877688 3367_ $$00$$2EndNote$$aJournal Article
000877688 520__ $$aRecent anecdotal and scientific reports have provided evidence of a link between COVID-19 and chemosensory impairments, such as anosmia. However, these reports have downplayed or failed to distinguish potential effects on taste, ignored chemesthesis, and generally lacked quantitative measurements. Here, we report the development, implementation, and initial results of a multilingual, international questionnaire to assess self-reported quantity and quality of perception in 3 distinct chemosensory modalities (smell, taste, and chemesthesis) before and during COVID-19. In the first 11 days after questionnaire launch, 4039 participants (2913 women, 1118 men, and 8 others, aged 19–79) reported a COVID-19 diagnosis either via laboratory tests or clinical assessment. Importantly, smell, taste, and chemesthetic function were each significantly reduced compared to their status before the disease. Difference scores (maximum possible change ±100) revealed a mean reduction of smell (−79.7 ± 28.7, mean ± standard deviation), taste (−69.0 ± 32.6), and chemesthetic (−37.3 ± 36.2) function during COVID-19. Qualitative changes in olfactory ability (parosmia and phantosmia) were relatively rare and correlated with smell loss. Importantly, perceived nasal obstruction did not account for smell loss. Furthermore, chemosensory impairments were similar between participants in the laboratory test and clinical assessment groups. These results show that COVID-19-associated chemosensory impairment is not limited to smell but also affects taste and chemesthesis. The multimodal impact of COVID-19 and the lack of perceived nasal obstruction suggest that severe acute respiratory syndrome coronavirus strain 2 (SARS-CoV-2) infection may disrupt sensory-neural mechanisms.
000877688 536__ $$0G:(DE-HGF)POF3-572$$a572 - (Dys-)function and Plasticity (POF3-572)$$cPOF3-572$$fPOF III$$x0
000877688 588__ $$aDataset connected to CrossRef
000877688 7001_ $$0P:(DE-Juel1)165362$$aOhla, Kathrin$$b1
000877688 7001_ $$0P:(DE-HGF)0$$aVeldhuizen, Maria G$$b2
000877688 7001_ $$0P:(DE-HGF)0$$aNiv, Masha Y$$b3
000877688 7001_ $$0P:(DE-HGF)0$$aKelly, Christine E$$b4
000877688 7001_ $$0P:(DE-HGF)0$$aBakke, Alyssa J$$b5
000877688 7001_ $$0P:(DE-HGF)0$$aCooper, Keiland W$$b6
000877688 7001_ $$0P:(DE-HGF)0$$aBouysset, Cédric$$b7
000877688 7001_ $$0P:(DE-HGF)0$$aPirastu, Nicola$$b8
000877688 7001_ $$0P:(DE-HGF)0$$aDibattista, Michele$$b9
000877688 7001_ $$0P:(DE-HGF)0$$aKaur, Rishemjit$$b10
000877688 7001_ $$0P:(DE-HGF)0$$aLiuzza, Marco Tullio$$b11
000877688 7001_ $$0P:(DE-HGF)0$$aPepino, Marta Y$$b12
000877688 7001_ $$0P:(DE-HGF)0$$aSchöpf, Veronika$$b13
000877688 7001_ $$0P:(DE-HGF)0$$aPereda-Loth, Veronica$$b14
000877688 7001_ $$0P:(DE-HGF)0$$aOlsson, Shannon B$$b15
000877688 7001_ $$0P:(DE-HGF)0$$aGerkin, Richard C$$b16
000877688 7001_ $$0P:(DE-HGF)0$$aRohlfs Domínguez, Paloma$$b17
000877688 7001_ $$0P:(DE-HGF)0$$aAlbayay, Javier$$b18
000877688 7001_ $$0P:(DE-HGF)0$$aFarruggia, Michael C$$b19
000877688 7001_ $$0P:(DE-HGF)0$$aBhutani, Surabhi$$b20
000877688 7001_ $$0P:(DE-HGF)0$$aFjaeldstad, Alexander W$$b21
000877688 7001_ $$0P:(DE-HGF)0$$aKumar, Ritesh$$b22
000877688 7001_ $$0P:(DE-HGF)0$$aMenini, Anna$$b23
000877688 7001_ $$0P:(DE-HGF)0$$aBensafi, Moustafa$$b24
000877688 7001_ $$0P:(DE-HGF)0$$aSandell, Mari$$b25
000877688 7001_ $$0P:(DE-HGF)0$$aKonstantinidis, Iordanis$$b26
000877688 7001_ $$0P:(DE-HGF)0$$aDi Pizio, Antonella$$b27
000877688 7001_ $$0P:(DE-HGF)0$$aGenovese, Federica$$b28
000877688 7001_ $$0P:(DE-HGF)0$$aÖztürk, Lina$$b29
000877688 7001_ $$0P:(DE-HGF)0$$aThomas-Danguin, Thierry$$b30
000877688 7001_ $$0P:(DE-HGF)0$$aFrasnelli, Johannes$$b31
000877688 7001_ $$0P:(DE-HGF)0$$aBoesveldt, Sanne$$b32
000877688 7001_ $$0P:(DE-HGF)0$$aSaatci, Özlem$$b33
000877688 7001_ $$0P:(DE-HGF)0$$aSaraiva, Luis R$$b34
000877688 7001_ $$0P:(DE-HGF)0$$aLin, Cailu$$b35
000877688 7001_ $$0P:(DE-HGF)0$$aGolebiowski, Jérôme$$b36
000877688 7001_ $$0P:(DE-HGF)0$$aDar Hwang, Liang-$$b37
000877688 7001_ $$0P:(DE-HGF)0$$aOzdener, Mehmet Hakan$$b38
000877688 7001_ $$0P:(DE-HGF)0$$aGuàrdia, Maria Dolors$$b39
000877688 7001_ $$0P:(DE-HGF)0$$aLaudamiel, Christophe$$b40
000877688 7001_ $$0P:(DE-HGF)0$$aRitchie, Marina$$b41
000877688 7001_ $$0P:(DE-HGF)0$$aHavlícek, Jan$$b42
000877688 7001_ $$0P:(DE-HGF)0$$aPierron, Denis$$b43
000877688 7001_ $$0P:(DE-HGF)0$$aRoura, Eugeni$$b44
000877688 7001_ $$0P:(DE-HGF)0$$aNavarro, Marta$$b45
000877688 7001_ $$0P:(DE-HGF)0$$aNolden, Alissa A$$b46
000877688 7001_ $$0P:(DE-HGF)0$$aLim, Juyun$$b47
000877688 7001_ $$0P:(DE-HGF)0$$aWhitcroft, K. L.$$b48
000877688 7001_ $$0P:(DE-HGF)0$$aColquitt, Lauren R$$b49
000877688 7001_ $$0P:(DE-HGF)0$$aFerdenzi, Camille$$b50
000877688 7001_ $$0P:(DE-HGF)0$$aBrindha, Evelyn V$$b51
000877688 7001_ $$0P:(DE-HGF)0$$aAltundag, Aytug$$b52
000877688 7001_ $$0P:(DE-HGF)0$$aMacchi, Alberto$$b53
000877688 7001_ $$0P:(DE-HGF)0$$aNunez-Parra, Alexia$$b54
000877688 7001_ $$0P:(DE-HGF)0$$aPatel, Zara M$$b55
000877688 7001_ $$0P:(DE-HGF)0$$aFiorucci, Sébastien$$b56
000877688 7001_ $$0P:(DE-HGF)0$$aPhilpott, Carl M$$b57
000877688 7001_ $$0P:(DE-HGF)0$$aSmith, Barry C$$b58
000877688 7001_ $$0P:(DE-HGF)0$$aLundström, Johan N$$b59
000877688 7001_ $$0P:(DE-HGF)0$$aMucignat, Carla$$b60
000877688 7001_ $$0P:(DE-HGF)0$$aParker, Jane K$$b61
000877688 7001_ $$0P:(DE-HGF)0$$avan den Brink, Mirjam$$b62
000877688 7001_ $$0P:(DE-HGF)0$$aSchmuker, Michael$$b63
000877688 7001_ $$0P:(DE-HGF)0$$aFischmeister, Florian Ph S$$b64
000877688 7001_ $$0P:(DE-HGF)0$$aHeinbockel, Thomas$$b65
000877688 7001_ $$0P:(DE-HGF)0$$aShields, Vonnie D C$$b66
000877688 7001_ $$0P:(DE-HGF)0$$aFaraji, Farhoud$$b67
000877688 7001_ $$0P:(DE-HGF)0$$aSantamaría, Enrique$$b68
000877688 7001_ $$0P:(DE-HGF)0$$aFredborg, William E A$$b69
000877688 7001_ $$0P:(DE-HGF)0$$aMorini, Gabriella$$b70
000877688 7001_ $$0P:(DE-HGF)0$$aOlofsson, Jonas K$$b71
000877688 7001_ $$0P:(DE-HGF)0$$aJalessi, Maryam$$b72
000877688 7001_ $$0P:(DE-HGF)0$$aKarni, Noam$$b73
000877688 7001_ $$0P:(DE-HGF)0$$aD’Errico, Anna$$b74
000877688 7001_ $$0P:(DE-HGF)0$$aAlizadeh, Rafieh$$b75
000877688 7001_ $$0P:(DE-HGF)0$$aPellegrino, Robert$$b76
000877688 7001_ $$0P:(DE-HGF)0$$aMeyer, Pablo$$b77
000877688 7001_ $$0P:(DE-HGF)0$$aHuart, Caroline$$b78
000877688 7001_ $$0P:(DE-HGF)0$$aChen, Ben$$b79
000877688 7001_ $$0P:(DE-HGF)0$$aSoler, Graciela M$$b80
000877688 7001_ $$0P:(DE-HGF)0$$aAlwashahi, Mohammed K$$b81
000877688 7001_ $$0P:(DE-HGF)0$$aWelge-Lüssen, Antje$$b82
000877688 7001_ $$0P:(DE-HGF)0$$aFreiherr, Jessica$$b83
000877688 7001_ $$0P:(DE-HGF)0$$ade Groot, Jasper H B$$b84
000877688 7001_ $$0P:(DE-HGF)0$$aKlein, Hadar$$b85
000877688 7001_ $$0P:(DE-HGF)0$$aOkamoto, Masako$$b86
000877688 7001_ $$0P:(DE-HGF)0$$aSingh, Preet Bano$$b87
000877688 7001_ $$0P:(DE-HGF)0$$aHsieh, Julien W$$b88
000877688 7001_ $$0P:(DE-HGF)0$$aReed, Danielle R$$b89
000877688 7001_ $$0P:(DE-HGF)0$$aHummel, Thomas$$b90
000877688 7001_ $$0P:(DE-HGF)0$$aMunger, Steven D$$b91
000877688 7001_ $$0P:(DE-HGF)0$$aHayes, John E$$b92$$eCorresponding author
000877688 7001_ $$0P:(DE-HGF)0$$aAbdulrahman, Olagunju$$b93
000877688 7001_ $$0P:(DE-HGF)0$$aDalton, Pamela$$b94
000877688 7001_ $$0P:(DE-HGF)0$$aYan, Carol H$$b95
000877688 7001_ $$0P:(DE-HGF)0$$aVoznessenskaya, Vera V$$b96
000877688 7001_ $$0P:(DE-HGF)0$$aChen, Jingguo$$b97
000877688 7001_ $$0P:(DE-HGF)0$$aSell, Elizabeth A$$b98
000877688 7001_ $$0P:(DE-HGF)0$$aWalsh-Messinger, Julie$$b99
000877688 7001_ $$0P:(DE-HGF)0$$aArcher, Nicholas S$$b100
000877688 7001_ $$0P:(DE-HGF)0$$aKoyama, Sachiko$$b101
000877688 7001_ $$0P:(DE-HGF)0$$aDeary, Vincent$$b102
000877688 7001_ $$0P:(DE-HGF)0$$aRoberts, S Craig$$b103
000877688 7001_ $$0P:(DE-HGF)0$$aYanik, Hüseyin$$b104
000877688 7001_ $$0P:(DE-HGF)0$$aAlbayrak, Samet$$b105
000877688 7001_ $$0P:(DE-HGF)0$$aNováková, Lenka Martinec$$b106
000877688 7001_ $$0P:(DE-HGF)0$$aCroijmans, Ilja$$b107
000877688 7001_ $$0P:(DE-HGF)0$$aMazal, Patricia Portillo$$b108
000877688 7001_ $$0P:(DE-HGF)0$$aMoein, Shima T$$b109
000877688 7001_ $$0P:(DE-HGF)0$$aMargulis, Eitan$$b110
000877688 7001_ $$0P:(DE-HGF)0$$aMignot, Coralie$$b111
000877688 7001_ $$0P:(DE-HGF)0$$aMariño, Sajidxa$$b112
000877688 7001_ $$0P:(DE-HGF)0$$aGeorgiev, Dejan$$b113
000877688 7001_ $$0P:(DE-HGF)0$$aKaushik, Pavan K$$b114
000877688 7001_ $$0P:(DE-HGF)0$$aMalnic, Bettina$$b115
000877688 7001_ $$0P:(DE-HGF)0$$aWang, Hong$$b116
000877688 7001_ $$0P:(DE-HGF)0$$aSeyed-Allaei, Shima$$b117
000877688 7001_ $$0P:(DE-HGF)0$$aYoluk, Nur$$b118
000877688 7001_ $$0P:(DE-HGF)0$$aRazzaghi-Asl, Sara$$b119
000877688 7001_ $$0P:(DE-HGF)0$$aJustice, Jeb M$$b120
000877688 7001_ $$0P:(DE-HGF)0$$aRestrepo, Diego$$b121
000877688 773__ $$0PERI:(DE-600)1494617-8$$a10.1093/chemse/bjaa041$$gp. bjaa041$$n7$$p609–622$$tChemical senses$$v45$$x1464-3553$$y2020
000877688 8564_ $$uhttps://juser.fz-juelich.de/record/877688/files/bjaa041.pdf$$yOpenAccess
000877688 8564_ $$uhttps://juser.fz-juelich.de/record/877688/files/bjaa041.pdf?subformat=pdfa$$xpdfa$$yOpenAccess
000877688 909CO $$ooai:juser.fz-juelich.de:877688$$pdnbdelivery$$pdriver$$pVDB$$popen_access$$popenaire
000877688 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)165362$$aForschungszentrum Jülich$$b1$$kFZJ
000877688 9131_ $$0G:(DE-HGF)POF3-572$$1G:(DE-HGF)POF3-570$$2G:(DE-HGF)POF3-500$$3G:(DE-HGF)POF3$$4G:(DE-HGF)POF$$aDE-HGF$$bKey Technologies$$lDecoding the Human Brain$$v(Dys-)function and Plasticity$$x0
000877688 9141_ $$y2020
000877688 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS$$d2020-01-18
000877688 915__ $$0StatID:(DE-HGF)0160$$2StatID$$aDBCoverage$$bEssential Science Indicators$$d2020-01-18
000877688 915__ $$0StatID:(DE-HGF)1030$$2StatID$$aDBCoverage$$bCurrent Contents - Life Sciences$$d2020-01-18
000877688 915__ $$0StatID:(DE-HGF)1190$$2StatID$$aDBCoverage$$bBiological Abstracts$$d2020-01-18
000877688 915__ $$0StatID:(DE-HGF)1040$$2StatID$$aDBCoverage$$bZoological Record$$d2020-01-18
000877688 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bCHEM SENSES : 2018$$d2020-01-18
000877688 915__ $$0LIC:(DE-HGF)CCBYNC4$$2HGFVOC$$aCreative Commons Attribution-NonCommercial CC BY-NC 4.0
000877688 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection$$d2020-01-18
000877688 915__ $$0StatID:(DE-HGF)0110$$2StatID$$aWoS$$bScience Citation Index$$d2020-01-18
000877688 915__ $$0StatID:(DE-HGF)0111$$2StatID$$aWoS$$bScience Citation Index Expanded$$d2020-01-18
000877688 915__ $$0StatID:(DE-HGF)9900$$2StatID$$aIF < 5$$d2020-01-18
000877688 915__ $$0StatID:(DE-HGF)0510$$2StatID$$aOpenAccess
000877688 915__ $$0StatID:(DE-HGF)1060$$2StatID$$aDBCoverage$$bCurrent Contents - Agriculture, Biology and Environmental Sciences$$d2020-01-18
000877688 915__ $$0StatID:(DE-HGF)0310$$2StatID$$aDBCoverage$$bNCBI Molecular Biology Database$$d2020-01-18
000877688 915__ $$0StatID:(DE-HGF)1050$$2StatID$$aDBCoverage$$bBIOSIS Previews$$d2020-01-18
000877688 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline$$d2020-01-18
000877688 915__ $$0StatID:(DE-HGF)0320$$2StatID$$aDBCoverage$$bPubMed Central$$d2020-01-18
000877688 915__ $$0StatID:(DE-HGF)0420$$2StatID$$aNationallizenz$$d2020-01-18$$wger
000877688 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bClarivate Analytics Master Journal List$$d2020-01-18
000877688 920__ $$lyes
000877688 9201_ $$0I:(DE-Juel1)INM-3-20090406$$kINM-3$$lKognitive Neurowissenschaften$$x0
000877688 980__ $$ajournal
000877688 980__ $$aVDB
000877688 980__ $$aUNRESTRICTED
000877688 980__ $$aI:(DE-Juel1)INM-3-20090406
000877688 9801_ $$aFullTexts