TY  - JOUR
AU  - Parma, Valentina
AU  - Ohla, Kathrin
AU  - Veldhuizen, Maria G
AU  - Niv, Masha Y
AU  - Kelly, Christine E
AU  - Bakke, Alyssa J
AU  - Cooper, Keiland W
AU  - Bouysset, Cédric
AU  - Pirastu, Nicola
AU  - Dibattista, Michele
AU  - Kaur, Rishemjit
AU  - Liuzza, Marco Tullio
AU  - Pepino, Marta Y
AU  - Schöpf, Veronika
AU  - Pereda-Loth, Veronica
AU  - Olsson, Shannon B
AU  - Gerkin, Richard C
AU  - Rohlfs Domínguez, Paloma
AU  - Albayay, Javier
AU  - Farruggia, Michael C
AU  - Bhutani, Surabhi
AU  - Fjaeldstad, Alexander W
AU  - Kumar, Ritesh
AU  - Menini, Anna
AU  - Bensafi, Moustafa
AU  - Sandell, Mari
AU  - Konstantinidis, Iordanis
AU  - Di Pizio, Antonella
AU  - Genovese, Federica
AU  - Öztürk, Lina
AU  - Thomas-Danguin, Thierry
AU  - Frasnelli, Johannes
AU  - Boesveldt, Sanne
AU  - Saatci, Özlem
AU  - Saraiva, Luis R
AU  - Lin, Cailu
AU  - Golebiowski, Jérôme
AU  - Dar Hwang, Liang-
AU  - Ozdener, Mehmet Hakan
AU  - Guàrdia, Maria Dolors
AU  - Laudamiel, Christophe
AU  - Ritchie, Marina
AU  - Havlícek, Jan
AU  - Pierron, Denis
AU  - Roura, Eugeni
AU  - Navarro, Marta
AU  - Nolden, Alissa A
AU  - Lim, Juyun
AU  - Whitcroft, K. L.
AU  - Colquitt, Lauren R
AU  - Ferdenzi, Camille
AU  - Brindha, Evelyn V
AU  - Altundag, Aytug
AU  - Macchi, Alberto
AU  - Nunez-Parra, Alexia
AU  - Patel, Zara M
AU  - Fiorucci, Sébastien
AU  - Philpott, Carl M
AU  - Smith, Barry C
AU  - Lundström, Johan N
AU  - Mucignat, Carla
AU  - Parker, Jane K
AU  - van den Brink, Mirjam
AU  - Schmuker, Michael
AU  - Fischmeister, Florian Ph S
AU  - Heinbockel, Thomas
AU  - Shields, Vonnie D C
AU  - Faraji, Farhoud
AU  - Santamaría, Enrique
AU  - Fredborg, William E A
AU  - Morini, Gabriella
AU  - Olofsson, Jonas K
AU  - Jalessi, Maryam
AU  - Karni, Noam
AU  - D’Errico, Anna
AU  - Alizadeh, Rafieh
AU  - Pellegrino, Robert
AU  - Meyer, Pablo
AU  - Huart, Caroline
AU  - Chen, Ben
AU  - Soler, Graciela M
AU  - Alwashahi, Mohammed K
AU  - Welge-Lüssen, Antje
AU  - Freiherr, Jessica
AU  - de Groot, Jasper H B
AU  - Klein, Hadar
AU  - Okamoto, Masako
AU  - Singh, Preet Bano
AU  - Hsieh, Julien W
AU  - Reed, Danielle R
AU  - Hummel, Thomas
AU  - Munger, Steven D
AU  - Hayes, John E
AU  - Abdulrahman, Olagunju
AU  - Dalton, Pamela
AU  - Yan, Carol H
AU  - Voznessenskaya, Vera V
AU  - Chen, Jingguo
AU  - Sell, Elizabeth A
AU  - Walsh-Messinger, Julie
AU  - Archer, Nicholas S
AU  - Koyama, Sachiko
AU  - Deary, Vincent
AU  - Roberts, S Craig
AU  - Yanik, Hüseyin
AU  - Albayrak, Samet
AU  - Nováková, Lenka Martinec
AU  - Croijmans, Ilja
AU  - Mazal, Patricia Portillo
AU  - Moein, Shima T
AU  - Margulis, Eitan
AU  - Mignot, Coralie
AU  - Mariño, Sajidxa
AU  - Georgiev, Dejan
AU  - Kaushik, Pavan K
AU  - Malnic, Bettina
AU  - Wang, Hong
AU  - Seyed-Allaei, Shima
AU  - Yoluk, Nur
AU  - Razzaghi-Asl, Sara
AU  - Justice, Jeb M
AU  - Restrepo, Diego
TI  - More than smell – COVID-19 is associated with severe impairment of smell, taste, and chemesthesis
JO  - Chemical senses
VL  - 45
IS  - 7
SN  - 1464-3553
CY  - Oxford
PB  - Oxford Univ. Press
M1  - FZJ-2020-02398
SP  - 609–622
PY  - 2020
AB  - Recent anecdotal and scientific reports have provided evidence of a link between COVID-19 and chemosensory impairments, such as anosmia. However, these reports have downplayed or failed to distinguish potential effects on taste, ignored chemesthesis, and generally lacked quantitative measurements. Here, we report the development, implementation, and initial results of a multilingual, international questionnaire to assess self-reported quantity and quality of perception in 3 distinct chemosensory modalities (smell, taste, and chemesthesis) before and during COVID-19. In the first 11 days after questionnaire launch, 4039 participants (2913 women, 1118 men, and 8 others, aged 19–79) reported a COVID-19 diagnosis either via laboratory tests or clinical assessment. Importantly, smell, taste, and chemesthetic function were each significantly reduced compared to their status before the disease. Difference scores (maximum possible change ±100) revealed a mean reduction of smell (−79.7 ± 28.7, mean ± standard deviation), taste (−69.0 ± 32.6), and chemesthetic (−37.3 ± 36.2) function during COVID-19. Qualitative changes in olfactory ability (parosmia and phantosmia) were relatively rare and correlated with smell loss. Importantly, perceived nasal obstruction did not account for smell loss. Furthermore, chemosensory impairments were similar between participants in the laboratory test and clinical assessment groups. These results show that COVID-19-associated chemosensory impairment is not limited to smell but also affects taste and chemesthesis. The multimodal impact of COVID-19 and the lack of perceived nasal obstruction suggest that severe acute respiratory syndrome coronavirus strain 2 (SARS-CoV-2) infection may disrupt sensory-neural mechanisms.
LB  - PUB:(DE-HGF)16
C6  - pmid:32564071
UR  - <Go to ISI:>//WOS:000591530900014
DO  - DOI:10.1093/chemse/bjaa041
UR  - https://juser.fz-juelich.de/record/877688
ER  -