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000877691 1001_ $$0P:(DE-Juel1)143792$$aGalldiks, Norbert$$b0$$eCorresponding author
000877691 245__ $$aImaging challenges following newer treatment options: Are companion diagnostics required in neurooncology?
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000877691 520__ $$aContrast-enhanced MRI is the method of choice for follow-up imaging in patients with brain tumors, but its specificity is low despite outstanding spatial resolution [1,2]. Importantly, the differentiation of treatment-related changes from actual tumor progression following newer treatment options such as immunotherapy using checkpoint inhibitors or vaccines is challenging by anatomical MRI alone [2–4]. Specifically, inflammation with intratumoral T-cell infiltrates triggered by immunotherapy may lead to highly variable MR imaging findings including contrast enhancement that may suggest tumor progression. Moreover, neuroimaging changes induced by these treatment options may also hamper a reliable response assessment.
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000877691 7001_ $$0P:(DE-Juel1)145110$$aLohmann, Philipp$$b1
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000877691 773__ $$0PERI:(DE-600)2090852-0$$a10.1080/14737159.2020.1782191$$gp. 14737159.2020.1782191$$n7$$p651-652$$tExpert review of molecular diagnostics$$v20$$x1744-8352$$y2020
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