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@ARTICLE{Galldiks:877691,
      author       = {Galldiks, Norbert and Lohmann, Philipp and Langen,
                      Karl-Josef},
      title        = {{I}maging challenges following newer treatment options:
                      {A}re companion diagnostics required in neurooncology?},
      journal      = {Expert review of molecular diagnostics},
      volume       = {20},
      number       = {7},
      issn         = {1744-8352},
      address      = {Abingdon},
      publisher    = {Taylor $\&$ Francis Group},
      reportid     = {FZJ-2020-02401},
      pages        = {651-652},
      year         = {2020},
      abstract     = {Contrast-enhanced MRI is the method of choice for follow-up
                      imaging in patients with brain tumors, but its specificity
                      is low despite outstanding spatial resolution [1,2].
                      Importantly, the differentiation of treatment-related
                      changes from actual tumor progression following newer
                      treatment options such as immunotherapy using checkpoint
                      inhibitors or vaccines is challenging by anatomical MRI
                      alone [2–4]. Specifically, inflammation with intratumoral
                      T-cell infiltrates triggered by immunotherapy may lead to
                      highly variable MR imaging findings including contrast
                      enhancement that may suggest tumor progression. Moreover,
                      neuroimaging changes induced by these treatment options may
                      also hamper a reliable response assessment.},
      cin          = {INM-3 / INM-4},
      ddc          = {570},
      cid          = {I:(DE-Juel1)INM-3-20090406 / I:(DE-Juel1)INM-4-20090406},
      pnm          = {572 - (Dys-)function and Plasticity (POF3-572)},
      pid          = {G:(DE-HGF)POF3-572},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:32552245},
      UT           = {WOS:000549555100001},
      doi          = {10.1080/14737159.2020.1782191},
      url          = {https://juser.fz-juelich.de/record/877691},
}