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| Home > Publications database > Imaging challenges following newer treatment options: Are companion diagnostics required in neurooncology? > print |
| 001 | 877691 | ||
| 005 | 20210130005214.0 | ||
| 024 | 7 | _ | |a 10.1080/14737159.2020.1782191 |2 doi |
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| 100 | 1 | _ | |a Galldiks, Norbert |0 P:(DE-Juel1)143792 |b 0 |e Corresponding author |
| 245 | _ | _ | |a Imaging challenges following newer treatment options: Are companion diagnostics required in neurooncology? |
| 260 | _ | _ | |a Abingdon |c 2020 |b Taylor & Francis Group |
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| 520 | _ | _ | |a Contrast-enhanced MRI is the method of choice for follow-up imaging in patients with brain tumors, but its specificity is low despite outstanding spatial resolution [1,2]. Importantly, the differentiation of treatment-related changes from actual tumor progression following newer treatment options such as immunotherapy using checkpoint inhibitors or vaccines is challenging by anatomical MRI alone [2–4]. Specifically, inflammation with intratumoral T-cell infiltrates triggered by immunotherapy may lead to highly variable MR imaging findings including contrast enhancement that may suggest tumor progression. Moreover, neuroimaging changes induced by these treatment options may also hamper a reliable response assessment. |
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| 700 | 1 | _ | |a Lohmann, Philipp |0 P:(DE-Juel1)145110 |b 1 |
| 700 | 1 | _ | |a Langen, Karl-Josef |0 P:(DE-Juel1)131777 |b 2 |
| 773 | _ | _ | |a 10.1080/14737159.2020.1782191 |g p. 14737159.2020.1782191 |0 PERI:(DE-600)2090852-0 |n 7 |p 651-652 |t Expert review of molecular diagnostics |v 20 |y 2020 |x 1744-8352 |
| 856 | 4 | _ | |y Restricted |u https://juser.fz-juelich.de/record/877691/files/Imaging%20challenges%20following%20newer%20treatment%20options%20are%20companion%20diagnostics%20required%20in%20neurooncology.pdf |
| 856 | 4 | _ | |y Published on 2020-06-30. Available in OpenAccess from 2021-06-30. |u https://juser.fz-juelich.de/record/877691/files/postprint_Imaging_challenges_NGalldiks.pdf |
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| 856 | 4 | _ | |y Published on 2020-06-30. Available in OpenAccess from 2021-06-30. |x pdfa |u https://juser.fz-juelich.de/record/877691/files/postprint_Imaging_challenges_NGalldiks.pdf?subformat=pdfa |
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