%0 Journal Article
%A Dietlein, Felix
%A Kobe, Carsten
%A Hohberg, Melanie
%A Zlatopolskiy, Boris D.
%A Krapf, Philipp
%A Endepols, Heike
%A Täger, Philipp
%A Hammes, Jochen
%A Heidenreich, Axel
%A Persigehl, Thorsten
%A Neumaier, Bernd
%A Drzezga, Alexander
%A Dietlein, Markus
%T Intraindividual Comparison of 18 F-PSMA-1007 with Renally Excreted PSMA Ligands for PSMA PET Imaging in Patients with Relapsed Prostate Cancer
%J Journal of nuclear medicine
%V 61
%N 5
%@ 2159-662X
%C New York, NY
%I Soc.
%M FZJ-2020-02483
%P 729 - 734
%D 2020
%X 18F-prostate-specific membrane antigen (PSMA)-1007 is excreted mainly through the liver. We benchmarked the performance of 18F-PSMA-1007 against 3 renally excreted PSMA tracers. Methods: Among 668 patients, we selected 27 in whom PET/CT results obtained with 68Ga-PSMA-11, 18F-DCFPyL (2-(3-(1-carboxy-5-[(6-[18F]fluoro-pyridine-3-carbonyl)-amino]-pentyl)-ureido)-pentanedioic acid), or 18F-JK-PSMA-7 (JK, Juelich-Koeln) were interpreted as equivocal or negative or as oligometastatic disease (PET-1). Within 3 wk, a second PET scan with 18F-PSMA-1007 was performed (PET-2). The confidence in the interpretation of PSMA-positive locoregional findings was scored on a 5-point scale, first in routine diagnostics (reader 1) and then by an independent second evaluation (reader 2). Discordant PSMA-positive skeletal findings were examined by contrast-enhanced MRI. Results: For both readers, 18F-PSMA-1007 facilitated the interpretability of 27 locoregional lesions. In PET-2, the clinical readout led to a significantly lower number of equivocal locoregional lesions (P = 0.024), and reader 2 reported a significantly higher rate of suspected lesions that were falsely interpreted as probably benign in PET-1 (P = 0.023). Exclusively in PET-2, we observed a total of 15 PSMA-positive spots in the bone marrow of 6 patients (22%). None of the 15 discordant spots had a morphologic correlate on the corresponding CT scan or on the subsequent MRI scan. Thus, 18F-PSMA-1007 exhibits a significantly higher rate of unspecific medullary spots (P = 0.0006). Conclusion: 18F-PSMA-1007 may increase confidence in interpreting small locoregional lesions adjacent to the urinary tract but may decrease the interpretability of skeletal lesions. 
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:31628219
%U <Go to ISI:>//WOS:000530836100024
%R 10.2967/jnumed.119.234898
%U https://juser.fz-juelich.de/record/877865