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@ARTICLE{Bajada:877949,
author = {Bajada, Claude J and Campos, Lucas Q Costa and Caspers,
Svenja and Muscat, Richard and Parker, Geoff J M and Ralph,
Matthew A Lambon and Cloutman, Lauren L and
Trujillo-Barreto, Nelson J},
title = {{A} tutorial and tool for exploring feature similarity
gradients with {MRI} data.},
journal = {NeuroImage},
volume = {221},
issn = {1053-8119},
address = {Orlando, Fla.},
publisher = {Academic Press},
reportid = {FZJ-2020-02528},
pages = {117140},
year = {2020},
abstract = {There has been an increasing interest in examining
organisational principles of the cerebral cortex (and
subcortical regions) using different MRI features such as
structural or functional connectivity. Despite the
widespread interest, introductory tutorials on the
underlying technique targeted for the novice neuroimager are
sparse in the literature. Articles that investigate various
'neural gradients' (for example based on region studied
'cortical gradients,' 'cerebellar gradients,' 'hippocampal
gradients' etc … or feature of interest 'functional
gradients,' 'cytoarchitectural gradients,'
'myeloarchitectural gradients' etc…) have increased in
popularity. Thus, we believe that it is opportune to discuss
what is generally meant by 'gradient analysis'. We introduce
basics concepts in graph theory, such as graphs themselves,
the degree matrix, and the adjacency matrix. We discuss how
one can think about gradients of feature similarity (the
similarity between timeseries in fMRI, or streamline in
tractography) using graph theory and we extend this to
explore such gradients across the whole MRI scale; from the
voxel level to the whole brain level. We proceed to
introduce a measure for quantifying the level of similarity
in regions of interest. We propose the term 'the Vogt-Bailey
index' for such quantification to pay homage to our history
as a brain mapping community. We run through the techniques
on sample datasets including a brain MRI as an example of
the application of the techniques on real data and we
provide several appendices that expand upon details. To
maximise intuition, the appendices contain a didactic
example describing how one could use these techniques to
solve a particularly pernicious problem that one may
encounter at a wedding. Accompanying the article is a tool,
available in both MATLAB and Python, that enables readers to
perform the analysis described in this article on their own
data. We refer readers to the graphical abstract as an
overview of the analysis pipeline presented in this work.},
cin = {INM-1},
ddc = {610},
cid = {I:(DE-Juel1)INM-1-20090406},
pnm = {571 - Connectivity and Activity (POF3-571) / HBP SGA2 -
Human Brain Project Specific Grant Agreement 2 (785907) /
HBP SGA3 - Human Brain Project Specific Grant Agreement 3
(945539)},
pid = {G:(DE-HGF)POF3-571 / G:(EU-Grant)785907 /
G:(EU-Grant)945539},
typ = {PUB:(DE-HGF)16},
pubmed = {pmid:32650053},
UT = {WOS:000600795000011},
doi = {10.1016/j.neuroimage.2020.117140},
url = {https://juser.fz-juelich.de/record/877949},
}