% IMPORTANT: The following is UTF-8 encoded. This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.
@ARTICLE{Kamitaki:877953,
author = {Kamitaki, Nolan and Sekar, Aswin and Handsaker, Robert E
and de Rivera, Heather and Tooley, Katherine and Morris,
David L and Taylor, Kimberly E and Whelan, Christopher W and
Tombleson, Philip and Loohuis, Loes M Olde and Consortium,
Schizophrenia Working Group of the Psychiatric Genomics and
Boehnke, Michael and Kimberly, Robert P and Kaufman, Kenneth
M and Harley, John B and Langefeld, Carl D and Seidman,
Christine E and Pato, Michele T and Pato, Carlos N and
Ophoff, Roel A and Graham, Robert R and Criswell, Lindsey A
and Vyse, Timothy J and McCarroll, Steven A and Ripke,
Stephan and Neale, Benjamin M and Corvin, Aiden and Walters,
James T R and Farh, Kai-How and Holmans, Peter A and Lee,
Phil and Bulik-Sullivan, Brendan and Collier, David A and
Huang, Hailiang and Pers, Tune H and Agartz, Ingrid and
Agerbo, Esben and Albus, Margot and Alexander, Madeline and
Amin, Farooq and Bacanu, Silviu A and Begemann, Martin and
Belliveau, Richard A and Bene, Judit and Bergen, Sarah E and
Bevilacqua, Elizabeth and Bigdeli, Tim B and Black, Donald W
and Bruggeman, Richard and Buccola, Nancy G and Buckner,
Randy L and Byerley, William and Cahn, Wiepke and Cai,
Guiqing and Cairns, Murray J and Campion, Dominique and
Cantor, Rita M and Carr, Vaughan J and Carrera, Noa and
Catts, Stanley V and Chambert, Kimberly D and Chan, Raymond
C K and Chen, Ronald Y L and Chen, Eric Y H and Cheng, Wei
and Cheung, Eric F C and Chong, Siow Ann and Cloninger, C
Robert and Cohen, David and Cohen, Nadine and Cormican, Paul
and Craddock, Nick and Crespo-Facorro, Benedicto and
Crowley, James J and Curtis, David and Davidson, Michael and
Davis, Kenneth L and Degenhardt, Franziska and Del Favero,
Jurgen and DeLisi, Lynn E and Demontis, Ditte and Dikeos,
Dimitris and Dinan, Timothy and Djurovic, Srdjan and
Donohoe, Gary and Drapeau, Elodie and Duan, Jubao and
Dudbridge, Frank and Durmishi, Naser and Eichhammer, Peter
and Eriksson, Johan and Escott-Price, Valentina and Essioux,
Laurent and Fanous, Ayman H and Farrell, Martilias S and
Frank, Josef and Franke, Lude and Freedman, Robert and
Freimer, Nelson B and Friedl, Marion and Friedman, Joseph I
and Fromer, Menachem and Genovese, Giulio and Georgieva,
Lyudmila and Gershon, Elliot S and Giegling, Ina and
Giusti-Rodríguez, Paola and Godard, Stephanie and
Goldstein, Jacqueline I and Golimbet, Vera and Gopal,
Srihari and Gratten, Jacob and de Haan, Lieuwe and Mitjans,
Marina and Hamshere, Marian L and Hansen, Mark and Hansen,
Thomas and Haroutunian, Vahram and Hartmann, Annette M and
Henskens, Frans A and Herms, Stefan and Hirschhorn, Joel N
and Hoffmann, Per and Hofman, Andrea and Hollegaard, Mads V
and Hougaard, David M and Ikeda, Masashi and Joa, Inge and
Julià, Antonio and Kahn, René S and Kalaydjieva, Luba and
Karachanak-Yankova, Sena and Karjalainen, Juha and Kavanagh,
David and Keller, Matthew C and Kelly, Brian J and Kennedy,
James L and Khrunin, Andrey and Kim, Yunjung and Klovins,
Janis and Knowles, James A and Konte, Bettina and Kucinskas,
Vaidutis and Kucinskiene, Zita Ausrele and
Kuzelova-Ptackova, Hana and Kähler, Anna K and Laurent,
Claudine and Keong, Jimmy Lee Chee and Lee, S Hong and
Legge, Sophie E and Lerer, Bernard and Li, Miaoxin and Li,
Tao and Liang, Kung-Yee and Lieberman, Jeffrey and
Limborska, Svetlana and Loughland, Carmel M and Lubinski,
Jan and Lönnqvist, Jouko and Macek, Milan and Magnusson,
Patrik K E and Maher, Brion S and Maier, Wolfgang and
Mallet, Jacques and Marsal, Sara and Mattheisen, Manuel and
Mattingsdal, Morten and McCarley, Robert W and McDonald,
Colm and McIntosh, Andrew M and Meier, Sandra and Meijer,
Carin J and Melegh, Bela and Melle, Ingrid and
Mesholam-Gately, Raquelle I and Metspalu, Andres and Michie,
Patricia T and Milani, Lili and Milanova, Vihra and Mokrab,
Younes and Morris, Derek W and Mors, Ole and Murphy, Kieran
C and Murray, Robin M and Myin-Germeys, Inez and
Müller-Myhsok, Bertram and Nelis, Mari and Nenadic, Igor
and Nertney, Deborah A and Nestadt, Gerald and Nicodemus,
Kristin K and Nikitina-Zake, Liene and Nisenbaum, Laura and
Nordin, Annelie and O'Callaghan, Eadbhard and O'Dushlaine,
Colm and O'Neill, F Anthony and Oh, Sang-Yun and Olincy, Ann
and Olsen, Line and Van Os, Jim and Pantelis, Christos and
Papadimitriou, George N and Steixner, Agnes A and
Parkhomenko, Elena and Pato, Michele T and Paunio, Tiina and
Pejovic-Milovancevic, Milica and Perkins, Diana O and
Pietiläinen, Olli and Pimm, Jonathan and Pocklington,
Andrew J and Powell, John and Price, Alkes and Pulver, Ann E
and Purcell, Shaun M and Quested, Digby and Rasmussen,
Henrik B and Reichenberg, Abraham and Reimers, Mark A and
Richards, Alexander L and Roffman, Joshua L and Roussos,
Panos and Ruderfer, Douglas M and Salomaa, Veikko and
Sanders, Alan R and Schall, Ulrich and Schubert, Christian R
and Schulze, Thomas G and Schwab, Sibylle G and Scolnick,
Edward M and Scott, Rodney J and Seidman, Larry J and Shi,
Jianxin and Sigurdsson, Engilbert and Silagadze, Teimuraz
and Silverman, Jeremy M and Sim, Kang and Slominsky, Petr
and Smoller, Jordan W and So, Hon-Cheong and Spencer, Chris
C A and Stahl, Eli A and Stefansson, Hreinn and Steinberg,
Stacy and Stogmann, Elisabeth and Straub, Richard E and
Strengman, Eric and Strohmaier, Jana and Stroup, T Scott and
Subramaniam, Mythily and Suvisaari, Jaana and Svrakic,
Dragan M and Szatkiewicz, Jin P and Söderman, Erik and
Thirumalai, Srinivas and Toncheva, Draga and Tooney, Paul A
and Tosato, Sarah and Veijola, Juha and Waddington, John and
Walsh, Dermot and Wang, Dai and Wang, Qiang and Webb,
Bradley T and Weiser, Mark and Wildenauer, Dieter B and
Williams, Nigel M and Williams, Stephanie and Witt,
Stephanie H and Wolen, Aaron R and Wong, Emily H M and
Wormley, Brandon K and Wu, Jing Qin and Xi, Hualin Simon and
Zai, Clement C and Zheng, Xuebin and Zimprich, Fritz and
Wray, Naomi R and Stefansson, Kari and Visscher, Peter M and
Adolfsson, Rolf and Andreassen, Ole A and Blackwood, Douglas
H R and Bramon, Elvira and Buxbaum, Joseph D and Børglum,
Anders D and Cichon, Sven and Darvasi, Ariel and Domenici,
Enrico and Ehrenreich, Hannelore and Esko, Tõnu and Gejman,
Pablo V and Gill, Michael and Gurling, Hugh and Hultman,
Christina M and Iwata, Nakao and Jablensky, Assen V and
Jönsson, Erik G and Kendler, Kenneth S and Kirov, George
and Knight, Jo and Lencz, Todd and Levinson, Douglas F and
Li, Qingqin S and Liu, Jianjun and Malhotra, Anil K and
McCarroll, Steven A and McQuillin, Andrew and Moran,
Jennifer L and Mortensen, Preben B and Mowry, Bryan J and
Nöthen, Markus M and Ophoff, Roel A and Owen, Michael J and
Palotie, Aarno and Pato, Carlos N and Petryshen, Tracey L
and Posthuma, Danielle and Rietschel, Marcella and Riley,
Brien P and Rujescu, Dan and Sham, Pak C and Sklar, Pamela
and Clair, David St and Weinberger, Daniel R and Wendland,
Jens R and Werge, Thomas and Daly, Mark J and Sullivan,
Patrick F and O'Donovan, Michael C},
title = {{C}omplement genes contribute sex-biased vulnerability in
diverse disorders.},
journal = {Nature},
volume = {582},
number = {7813},
issn = {1476-4687},
address = {London [u.a.]},
publisher = {Nature Publ. Group78092},
reportid = {FZJ-2020-02532},
pages = {577 - 581},
year = {2020},
abstract = {Many common illnesses, for reasons that have not been
identified, differentially affect men and women. For
instance, the autoimmune diseases systemic lupus
erythematosus (SLE) and Sjögren's syndrome affect nine
times more women than men1, whereas schizophrenia affects
men with greater frequency and severity relative to women2.
All three illnesses have their strongest common genetic
associations in the major histocompatibility complex (MHC)
locus, an association that in SLE and Sjögren's syndrome
has long been thought to arise from alleles of the human
leukocyte antigen (HLA) genes at that locus3-6. Here we show
that variation of the complement component 4 (C4) genes C4A
and C4B, which are also at the MHC locus and have been
linked to increased risk for schizophrenia7, generates
7-fold variation in risk for SLE and 16-fold variation in
risk for Sjögren's syndrome among individuals with common
C4 genotypes, with C4A protecting more strongly than C4B in
both illnesses. The same alleles that increase risk for
schizophrenia greatly reduce risk for SLE and Sjögren's
syndrome. In all three illnesses, C4 alleles act more
strongly in men than in women: common combinations of C4A
and C4B generated 14-fold variation in risk for SLE, 31-fold
variation in risk for Sjögren's syndrome, and 1.7-fold
variation in schizophrenia risk among men (versus 6-fold,
15-fold and 1.26-fold variation in risk among women,
respectively). At a protein level, both C4 and its effector
C3 were present at higher levels in cerebrospinal fluid and
plasma8,9 in men than in women among adults aged between 20
and 50 years, corresponding to the ages of differential
disease vulnerability. Sex differences in complement protein
levels may help to explain the more potent effects of C4
alleles in men, women's greater risk of SLE and Sjögren's
syndrome and men's greater vulnerability to schizophrenia.
These results implicate the complement system as a source of
sexual dimorphism in vulnerability to diverse illnesses.},
cin = {INM-1},
ddc = {500},
cid = {I:(DE-Juel1)INM-1-20090406},
pnm = {571 - Connectivity and Activity (POF3-571)},
pid = {G:(DE-HGF)POF3-571},
typ = {PUB:(DE-HGF)16},
pubmed = {pmid:32499649},
pmc = {pmc:PMC7319891},
UT = {WOS:000585013200013},
doi = {10.1038/s41586-020-2277-x},
url = {https://juser.fz-juelich.de/record/877953},
}
guest ::