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@ARTICLE{Thieme:877976,
      author       = {Thieme, A. and Röske, S. and Faber, J. and Sulzer, P. and
                      Minnerop, Martina and Elben, S. and Jacobi, H. and Reetz,
                      Kathrin and Dogan, I. and Barkhoff, M. and Konczak, J. and
                      Wondzinski, E. and Siebler , M. and Müller, O. and Sure, U.
                      and Schmahmann, J. D. and Klockgether, T. and Synofzik, M.
                      and Timmann, D.},
      title        = {{V}alidation of a {G}erman version of the {C}erebellar
                      {C}ognitive {A}ffective/{S}chmahmann {S}yndrome {S}cale:
                      preliminary version and study protocol},
      journal      = {Neurological research and practice},
      volume       = {2},
      issn         = {2524-3489},
      address      = {[London]},
      publisher    = {BioMed Central},
      reportid     = {FZJ-2020-02553},
      pages        = {39},
      year         = {2020},
      abstract     = {BackgroundTraditionally, cerebellar disorders including
                      ataxias have been associated with deficits in motor control
                      and motor learning. Since the 1980’s growing evidence has
                      emerged that cerebellar diseases also impede cognitive and
                      affective processes such as executive and linguistic
                      functions, visuospatial abilities and regulation of emotion
                      and affect. This combination of non-motor symptoms has been
                      named Cerebellar Cognitive Affective/ Schmahmann Syndrome
                      (CCAS). To date, diagnosis relies on non-standardized
                      bedside cognitive examination and, if available, detailed
                      neuropsychological test batteries. Recently, a short and
                      easy applicable bedside test (CCAS Scale) has been developed
                      to screen for CCAS. It has been validated in an US-American
                      cohort of adults with cerebellar disorders and healthy
                      controls. As yet, the CCAS Scale has only been available in
                      American English. We present a German version of the scale
                      and the study protocol of its ongoing validation in a
                      German-speaking patient cohort.MethodsA preliminary German
                      version has been created from the original CCAS Scale using
                      a standardized translation procedure. This version has been
                      pre-tested in cerebellar patients and healthy controls
                      including medical experts and laypersons to ensure that
                      instructions are well understandable, and that no
                      information has been lost or added during translation. This
                      preliminary German version will be validated in a minimum of
                      65 patients with cerebellar disease and 65 matched healthy
                      controls. We test whether selectivity and sensitivity of the
                      German CCAS Scale is comparable to the original CCAS Scale
                      using the same cut-off values for each of the test items,
                      and the same pass/ fail criteria to determine the presence
                      of CCAS. Furthermore, internal consistency, test-retest and
                      interrater reliability will be evaluated. In addition,
                      construct validity will be tested in a subset of patients
                      and controls in whom detailed neuropsychological testing
                      will be available. Secondary aims will be examination of
                      possible correlations between clinical features (e.g.
                      disease duration, clinical ataxia scores) and CCAS
                      scores.PerspectiveThe overall aim is to deliver a validated
                      bedside test to screen for CCAS in German-speaking patients
                      which can also be used in future natural history and
                      therapeutic trials.},
      cin          = {INM-1},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-1-20090406},
      pnm          = {571 - Connectivity and Activity (POF3-571)},
      pid          = {G:(DE-HGF)POF3-571},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {33324939},
      UT           = {WOS:001050016900001},
      doi          = {10.1186/s42466-020-00071-3},
      url          = {https://juser.fz-juelich.de/record/877976},
}