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000878000 1001_ $$0P:(DE-HGF)0$$aPijnenborg, G. H. M.$$b0$$eCorresponding author
000878000 245__ $$aBrain areas associated with clinical and cognitive insight in psychotic disorders: A systematic review and meta-analysis
000878000 260__ $$aAmsterdam [u.a.]$$bElsevier Science$$c2020
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000878000 500__ $$aAcknowledgementThis work was supported by a European Young Investigator Awardof the European Science Foundation (no. 044035001) awarded to A.A.
000878000 520__ $$an the past years, ample interest in brain abnormalities related to clinical and cognitive insight in psychosis has contributed several neuroimaging studies to the literature. In the current study, published findings on the neural substrates of clinical and cognitive insight in psychosis are integrated by performing a systematic review and meta-analysis.Coordinate-based meta-analyses were performed with the parametric coordinate-based meta-analysis approach, non-coordinate based meta-analyses were conducted with the metafor package in R. Papers that could not be included in the meta-analyses were systematically reviewed.Thirty-seven studies were retrieved, of which 21 studies were included in meta-analyses. Poorer clinical insight was related to smaller whole brain gray and white matter volume and gray matter volume of the frontal gyri. Cognitive insight was predominantly positively associated with structure and function of the hippocampus and ventrolateral prefrontal cortex.Impaired clinical insight is not associated with abnormalities of isolated brain regions, but with spatially diffuse global and frontal abnormalities suggesting it might rely on a range of cognitive and self-evaluative processes. Cognitive insight is associated with specific areas and appears to rely more on retrieving and integrating self-related information.
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000878000 7001_ $$0P:(DE-Juel1)180372$$aLarabi, D. I.$$b1$$ufzj
000878000 7001_ $$aXu, P.$$b2
000878000 7001_ $$aHasson-Ohayon, I.$$b3
000878000 7001_ $$ade Vos, A. E.$$b4
000878000 7001_ $$aĆurčić-Blake, B.$$b5
000878000 7001_ $$aAleman, A.$$b6
000878000 7001_ $$aVan der Meer, L.$$b7
000878000 773__ $$0PERI:(DE-600)1498433-7$$a10.1016/j.neubiorev.2020.06.022$$gVol. 116, p. 301 - 336$$p301 - 336$$tNeuroscience & biobehavioral reviews$$v116$$x0149-7634$$y2020
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