TY  - JOUR
AU  - Pijnenborg, G. H. M.
AU  - Larabi, D. I.
AU  - Xu, P.
AU  - Hasson-Ohayon, I.
AU  - de Vos, A. E.
AU  - Ćurčić-Blake, B.
AU  - Aleman, A.
AU  - Van der Meer, L.
TI  - Brain areas associated with clinical and cognitive insight in psychotic disorders: A systematic review and meta-analysis
JO  - Neuroscience & biobehavioral reviews
VL  - 116
SN  - 0149-7634
CY  - Amsterdam [u.a.]
PB  - Elsevier Science
M1  - FZJ-2020-02574
SP  - 301 - 336
PY  - 2020
N1  - AcknowledgementThis work was supported by a European Young Investigator Awardof the European Science Foundation (no. 044035001) awarded to A.A.
AB  - n the past years, ample interest in brain abnormalities related to clinical and cognitive insight in psychosis has contributed several neuroimaging studies to the literature. In the current study, published findings on the neural substrates of clinical and cognitive insight in psychosis are integrated by performing a systematic review and meta-analysis.Coordinate-based meta-analyses were performed with the parametric coordinate-based meta-analysis approach, non-coordinate based meta-analyses were conducted with the metafor package in R. Papers that could not be included in the meta-analyses were systematically reviewed.Thirty-seven studies were retrieved, of which 21 studies were included in meta-analyses. Poorer clinical insight was related to smaller whole brain gray and white matter volume and gray matter volume of the frontal gyri. Cognitive insight was predominantly positively associated with structure and function of the hippocampus and ventrolateral prefrontal cortex.Impaired clinical insight is not associated with abnormalities of isolated brain regions, but with spatially diffuse global and frontal abnormalities suggesting it might rely on a range of cognitive and self-evaluative processes. Cognitive insight is associated with specific areas and appears to rely more on retrieving and integrating self-related information.
LB  - PUB:(DE-HGF)16
C6  - pmid:32569706
UR  - <Go to ISI:>//WOS:000557868200024
DO  - DOI:10.1016/j.neubiorev.2020.06.022
UR  - https://juser.fz-juelich.de/record/878000
ER  -