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@ARTICLE{Pijnenborg:878000,
      author       = {Pijnenborg, G. H. M. and Larabi, D. I. and Xu, P. and
                      Hasson-Ohayon, I. and de Vos, A. E. and Ćurčić-Blake, B.
                      and Aleman, A. and Van der Meer, L.},
      title        = {{B}rain areas associated with clinical and cognitive
                      insight in psychotic disorders: {A} systematic review and
                      meta-analysis},
      journal      = {Neuroscience $\&$ biobehavioral reviews},
      volume       = {116},
      issn         = {0149-7634},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier Science},
      reportid     = {FZJ-2020-02574},
      pages        = {301 - 336},
      year         = {2020},
      note         = {AcknowledgementThis work was supported by a European Young
                      Investigator Awardof the European Science Foundation (no.
                      044035001) awarded to A.A.},
      abstract     = {n the past years, ample interest in brain abnormalities
                      related to clinical and cognitive insight in psychosis has
                      contributed several neuroimaging studies to the literature.
                      In the current study, published findings on the neural
                      substrates of clinical and cognitive insight in psychosis
                      are integrated by performing a systematic review and
                      meta-analysis.Coordinate-based meta-analyses were performed
                      with the parametric coordinate-based meta-analysis approach,
                      non-coordinate based meta-analyses were conducted with the
                      metafor package in R. Papers that could not be included in
                      the meta-analyses were systematically reviewed.Thirty-seven
                      studies were retrieved, of which 21 studies were included in
                      meta-analyses. Poorer clinical insight was related to
                      smaller whole brain gray and white matter volume and gray
                      matter volume of the frontal gyri. Cognitive insight was
                      predominantly positively associated with structure and
                      function of the hippocampus and ventrolateral prefrontal
                      cortex.Impaired clinical insight is not associated with
                      abnormalities of isolated brain regions, but with spatially
                      diffuse global and frontal abnormalities suggesting it might
                      rely on a range of cognitive and self-evaluative processes.
                      Cognitive insight is associated with specific areas and
                      appears to rely more on retrieving and integrating
                      self-related information.},
      cin          = {INM-7},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-7-20090406},
      pnm          = {573 - Neuroimaging (POF3-573)},
      pid          = {G:(DE-HGF)POF3-573},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:32569706},
      UT           = {WOS:000557868200024},
      doi          = {10.1016/j.neubiorev.2020.06.022},
      url          = {https://juser.fz-juelich.de/record/878000},
}