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@ARTICLE{Beckers:878063,
      author       = {Beckers, Maximilian and Sachse, Carsten},
      title        = {{P}ermutation testing of {F}ourier shell correlation for
                      resolution estimation of cryo-{EM} maps},
      journal      = {Journal of structural biology},
      volume       = {212},
      number       = {1},
      issn         = {1047-8477},
      address      = {San Diego, Calif.},
      publisher    = {Elsevier},
      reportid     = {FZJ-2020-02607},
      pages        = {107579 -},
      year         = {2020},
      abstract     = {Fourier shell correlation (FSC) has become a standard
                      quantity for resolution estimation in electron
                      cryo-microscopy. However, the resolution determination step
                      is still subjective and not fully automated as it involves a
                      series of map interventions before FSC computation and
                      includes the selection of a common threshold. Here, we apply
                      the statistical methods of permutation testing and false
                      discovery rate (FDR) control to the resolution-dependent
                      correlation measure. The approach allows fully automated and
                      mask-free resolution determination based on statistical
                      thresholding of FSC curves. We demonstrate the applicability
                      for global, local and directional resolution estimation and
                      show that the developed criterion termed FDR-FSC gives
                      realistic resolution estimates based on statistical
                      significance while eliminating the need of any map
                      manipulations. The algorithms are implemented in a
                      user-friendly GUI based software tool termed SPoC
                      (https://github.com/MaximilianBeckers/SPOC).},
      cin          = {ER-C-3},
      ddc          = {540},
      cid          = {I:(DE-Juel1)ER-C-3-20170113},
      pnm          = {551 - Functional Macromolecules and Complexes (POF3-551)},
      pid          = {G:(DE-HGF)POF3-551},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:32693019},
      UT           = {WOS:000574936400006},
      doi          = {10.1016/j.jsb.2020.107579},
      url          = {https://juser.fz-juelich.de/record/878063},
}