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@ARTICLE{Worthoff:878067,
      author       = {Worthoff, Wieland A. and Shymanskaya, Aliaksandra and
                      Lindemeyer, Johannes and Langen, Karl‐Josef and Shah, N.
                      Jon},
      title        = {{R}elaxometry and quantification in sodium {MRI} of
                      cerebral gliomas: {A} {FET}‐{PET} and {MRI} small‐scale
                      study},
      journal      = {NMR in biomedicine},
      volume       = {33},
      number       = {10},
      issn         = {1099-1492},
      address      = {New York, NY},
      publisher    = {Wiley},
      reportid     = {FZJ-2020-02609},
      pages        = {e4361},
      year         = {2020},
      abstract     = {Sodium MRI is a promising method for assessing the
                      metabolic properties of brain tumours. In a recent study, a
                      strong relationship between semi‐quantitative
                      abnormalities in sodium MRI and the mutational status of the
                      isocitrate dehydrogenase enzyme (IDH) with untreated
                      cerebral gliomas was observed. Here, sodium relaxometry in
                      brain tumour tissue was investigated in relation to
                      molecular markers in order to reveal quantitative sodium
                      tissue parameters and the differences between healthy tissue
                      and brain tumour. The previous semi‐quantitative approach
                      is extended by use of suitable relaxometry methods
                      accompanied by numerical simulation to achieve detailed
                      quantitative analysis of intra‐ and extracellular sodium
                      concentration using an enhanced SISTINA sequence at 4 T.
                      Using optimised techniques, biexponential sodium relaxation
                      times in tumour (T* 2f, T* 2s) and in healthy contralateral
                      brain tissue (T* 2f,CL, T* 2s,CL) were estimated in 10
                      patients, along with intracellular sodium molar fractions
                      (χ, χCL), volume fractions (η, ηCL) and concentrations
                      (ρin, ρin,CL). The total sodium tissue concentrations
                      (ρT, ρT,CL) were also estimated. The ratios T *2f/T *2f,CL
                      (P = .05), η/ηCL (P = .02) and χ/χCL (P = .02) were
                      significantly lower in IDH mutated than in IDH wildtype
                      gliomas (n = 4 and n = 5 patients, respectively). The
                      Wilcoxon rank‐sum test was used to compare sodium MRI
                      parameters in patients with and without IDH mutation. Thus,
                      quantitative analysis of relaxation rates, intra‐ and
                      extracellular sodium concentrations, intracellular molar and
                      volume fractions based on enhanced SISTINA confirmed a
                      relationship between abnormalities in sodium parameters and
                      the IDH mutational status in cerebral gliomas, hence
                      catering for the potential to provide further insights into
                      the status of the disease.},
      cin          = {INM-4 / INM-11 / JARA-BRAIN},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-4-20090406 / I:(DE-Juel1)INM-11-20170113 /
                      $I:(DE-82)080010_20140620$},
      pnm          = {573 - Neuroimaging (POF3-573)},
      pid          = {G:(DE-HGF)POF3-573},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:32696547},
      UT           = {WOS:000550643600001},
      doi          = {10.1002/nbm.4361},
      url          = {https://juser.fz-juelich.de/record/878067},
}