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@ARTICLE{Rosenbauer:878070,
      author       = {Rosenbauer, Jakob and Zhang, Chengting and Mattes, Benjamin
                      and Reinartz, Ines and Wedgwood, Kyle and Schindler, Simone
                      and Sinner, Claude and Scholpp, Steffen and Schug,
                      Alexander},
      title        = {{M}odeling of {W}nt-mediated tissue patterning in
                      vertebrate embryogenesis},
      journal      = {PLoS Computational Biology},
      volume       = {16},
      number       = {6},
      issn         = {1553-7358},
      address      = {San Francisco, Calif.},
      publisher    = {Public Library of Science},
      reportid     = {FZJ-2020-02612},
      pages        = {e1007417 -},
      year         = {2020},
      abstract     = {During embryogenesis, morphogens form a concentration
                      gradient in responsive tissue, which is then translated into
                      a spatial cellular pattern. The mechanisms by which
                      morphogens spread through a tissue to establish such a
                      morphogenetic field remain elusive. Here, we investigate by
                      mutually complementary simulations and in vivo experiments
                      how Wnt morphogen transport by cytonemes differs from
                      typically assumed diffusion-based transport for patterning
                      of highly dynamic tissue such as the neural plate in
                      zebrafish. Stochasticity strongly influences fate
                      acquisition at the single cell level and results in
                      fluctuating boundaries between pattern regions. Stable
                      patterning can be achieved by sorting through concentration
                      dependent cell migration and apoptosis, independent of the
                      morphogen transport mechanism. We show that Wnt transport by
                      cytonemes achieves distinct Wnt thresholds for the brain
                      primordia earlier compared with diffusion-based transport.
                      We conclude that a cytoneme-mediated morphogen transport
                      together with directed cell sorting is a potentially favored
                      mechanism to establish morphogen gradients in rapidly
                      expanding developmental systems.},
      cin          = {JSC / NIC},
      ddc          = {610},
      cid          = {I:(DE-Juel1)JSC-20090406 / I:(DE-Juel1)NIC-20090406},
      pnm          = {511 - Computational Science and Mathematical Methods
                      (POF3-511) / Forschergruppe Schug $(hkf6_20170901)$ / PhD no
                      Grant - Doktorand ohne besondere Förderung
                      (PHD-NO-GRANT-20170405)},
      pid          = {G:(DE-HGF)POF3-511 / $G:(DE-Juel1)hkf6_20170901$ /
                      G:(DE-Juel1)PHD-NO-GRANT-20170405},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:32579554},
      UT           = {WOS:000558077600003},
      doi          = {10.1371/journal.pcbi.1007417},
      url          = {https://juser.fz-juelich.de/record/878070},
}