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| Hauptseite > Publikationsdatenbank > Structural features of the glutamate-binding protein from Corynebacterium glutamicum > print |
| Hauptseite > Publikationsdatenbank > Structural features of the glutamate-binding protein from Corynebacterium glutamicum > print |
| 001 | 878105 | ||
| 005 | 20210130005404.0 | ||
| 024 | 7 | _ | |a 10.1016/j.ijbiomac.2020.06.197 |2 doi |
| 024 | 7 | _ | |a 0141-8130 |2 ISSN |
| 024 | 7 | _ | |a 1879-0003 |2 ISSN |
| 024 | 7 | _ | |a 2128/25405 |2 Handle |
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| 082 | _ | _ | |a 570 |
| 100 | 1 | _ | |a Capo, Alessandro |0 P:(DE-HGF)0 |b 0 |
| 245 | _ | _ | |a Structural features of the glutamate-binding protein from Corynebacterium glutamicum |
| 260 | _ | _ | |a New York, NY [u.a.] |c 2020 |b Elsevier |
| 336 | 7 | _ | |a article |2 DRIVER |
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| 500 | _ | _ | |a Biotechnologie 1 |
| 520 | _ | _ | |a L-glutamate (Glu) is the major excitatory transmitter in mammalian brain. Inadequate concentration of Glu in the brain correlates to mood disorder. In industry, Glu is used as a flavour enhancer in food and in foodstuff processing. A high concentration of Glu has several effects on human health such as hypersensitive effects, headache and stomach pain. The presence of Glu in food can be detected by different analytical methods based on chromatography, or capillary electrophoresis or amperometric techniques. We have isolated and characterized a glutamate-binding protein (GluB) from the Gram-positive bacteria Corynebacterium glutamicum. Together with GluC protein, GluD protein and the cytoplasmic protein GluA, GluB permits the transport of Glu in/out of cell.In this study, we have investigated the binding features of GluB as well as the effect of temperature on its structure both in the absence and in the presence of Glu. The results have showed that GluB has a high affinity and selectivity versus Glu (nanomolar range) and the presence of the ligand induces a higher thermal stability of the protein structure. |
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| 700 | 1 | _ | |a Natalello, Antonino |0 0000-0002-1489-272X |b 1 |
| 700 | 1 | _ | |a Marienhagen, Jan |0 P:(DE-Juel1)144031 |b 2 |
| 700 | 1 | _ | |a Pennacchio, Angela |0 P:(DE-HGF)0 |b 3 |
| 700 | 1 | _ | |a Camarca, Alessandra |0 P:(DE-HGF)0 |b 4 |
| 700 | 1 | _ | |a Di Giovanni, Stefano |0 P:(DE-HGF)0 |b 5 |
| 700 | 1 | _ | |a Staiano, Maria |0 P:(DE-HGF)0 |b 6 |
| 700 | 1 | _ | |a D'Auria, Sabato |0 P:(DE-HGF)0 |b 7 |e Corresponding author |
| 700 | 1 | _ | |a Varriale, Antonio |0 P:(DE-HGF)0 |b 8 |
| 773 | _ | _ | |a 10.1016/j.ijbiomac.2020.06.197 |g Vol. 162, p. 903 - 912 |0 PERI:(DE-600)1483284-7 |p 903 - 912 |t International journal of biological macromolecules |v 162 |y 2020 |x 0141-8130 |
| 856 | 4 | _ | |y Published on 2020-06-25. Available in OpenAccess from 2021-06-25. |z StatID:(DE-HGF)0510 |u https://juser.fz-juelich.de/record/878105/files/Capo%2C%20Marienhagen%20GluB%20structure%20of%20C.%20glutamicum%202020.pdf |
| 856 | 4 | _ | |y Published on 2020-06-25. Available in OpenAccess from 2021-06-25. |x pdfa |z StatID:(DE-HGF)0510 |u https://juser.fz-juelich.de/record/878105/files/Capo%2C%20Marienhagen%20GluB%20structure%20of%20C.%20glutamicum%202020.pdf?subformat=pdfa |
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