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@ARTICLE{Fahlke:878111,
      author       = {Fahlke, Christoph},
      title        = {{M}embrane {P}hysiology and {B}iophysics—{W}hat {R}emains
                      to {B}e {D}one?},
      journal      = {Frontiers in physiology},
      volume       = {11},
      issn         = {1664-042X},
      address      = {Lausanne},
      publisher    = {Frontiers Research Foundation},
      reportid     = {FZJ-2020-02638},
      pages        = {892},
      year         = {2020},
      abstract     = {Biological membranes consist of lipid bilayer matrices
                      enriched with integral membrane proteins and
                      membrane-associated proteins. They not only define cells and
                      cell organelles but also represent the main contact area for
                      intercellular communication, for which membrane transport
                      and signaling are indispensable. Because of their high
                      physiological importance and unique physical and chemical
                      properties, biological membranes have been intensively
                      studied for over 100 years, and membrane physiology remains
                      a flourishing and lively research field. Recent years have
                      witnessed great progress in our understanding of the
                      biophysical basis of membrane transport and its role in
                      generating biological electricity and controlling the
                      intracellular milieu. The workings of ion channels and
                      transporters are understood in a degree of detail that was
                      unimaginable when many of us started our scientific careers.
                      Protein sequences and three-dimensional structures are now
                      available for almost every major ion channel and transporter
                      family (Navratna and Gouaux, 2019). Heterologous expression
                      systems and patch clamp electrophysiology can provide
                      functional data of unprecedented accuracy (Neher, 1992;
                      Sakmann, 1992). The identification of amino acid sequences
                      that direct ion channels and transporters to specific
                      intracellular membrane compartments has enabled ion
                      transport proteins that normally reside in intracellular
                      membranes (such as synaptic vesicles or lysosomes) to be
                      expressed and studied on the plasma membrane of mammalian
                      cells (Leisle et al., 2011; Guzman et al., 2015; Eriksen et
                      al., 2016). Moreover, advances in live-cell imaging enable
                      the real-time visualization of intracellular trafficking of
                      ion channels and transporters from protein translation in
                      the endoplasmic reticulum to their arrival at the plasma
                      membrane or site of action (Xiao and Shaw, 2015; Conrad et
                      al., 2018).},
      cin          = {IBI-1},
      ddc          = {610},
      cid          = {I:(DE-Juel1)IBI-1-20200312},
      pnm          = {552 - Engineering Cell Function (POF3-552)},
      pid          = {G:(DE-HGF)POF3-552},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:32848847},
      UT           = {WOS:000561341200001},
      doi          = {10.3389/fphys.2020.00892},
      url          = {https://juser.fz-juelich.de/record/878111},
}