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@ARTICLE{Chen:878125,
      author       = {Chen, Xiangliang and Laurent, Sarah and Onur, Oezguer A.
                      and Kleineberg, Nina N. and Fink, Gereon R. and Schweitzer,
                      Finja and Warnke, Clemens},
      title        = {{A} systematic review of neurological symptoms and
                      complications of {COVID}-19},
      journal      = {Journal of neurology},
      volume       = {268},
      number       = {2},
      issn         = {0340-5354},
      address      = {Berlin},
      publisher    = {Springer85301},
      reportid     = {FZJ-2020-02643},
      pages        = {392-402},
      year         = {2021},
      abstract     = {ObjectiveTo study the frequency of neurological symptoms
                      and complications in COVID-19 patients in a systematic
                      review of the literature.MethodsRelevant studies were
                      identified through electronic explorations of PubMed,
                      medRxiv, and bioRxiv. Besides, three Chinese databases were
                      searched. A snowballing method searching the bibliographies
                      of the retrieved references was applied to identify
                      potentially relevant articles. Articles published within 1
                      year prior to April 20th, 2020, were screened with no
                      language restriction imposed. Databases were searched for
                      terms related to SARS-CoV-2/COVID-19 and neurological
                      manifestations, using a pre-established protocol registered
                      on the International Prospective Register of Systematic
                      Reviews database (ID: CRD42020187994).ResultsA total of 2441
                      articles were screened for relevant content, of which 92
                      full-text publications were included in the analyses of
                      neurological manifestations of COVID-19. Headache,
                      dizziness, taste and smell dysfunctions, and impaired
                      consciousness were the most frequently described
                      neurological symptoms, the latter more often among patients
                      with a severe or critical disease course. To date, only
                      smaller cohort studies or single cases have reported
                      cerebrovascular events, seizures, meningoencephalitis, and
                      immune-mediated neurological diseases, not suitable for
                      quantitative analysis.ConclusionThe most frequent
                      neurological symptoms reported in association with COVID-19
                      are non-specific for the infection with SARS-CoV-2. Although
                      SARS-CoV-2 may have the potential to gain direct access to
                      the nervous system, so far, SARS-CoV-2 was detected in the
                      cerebrospinal fluid in two cases only. Standardized
                      international registries are needed to clarify the clinical
                      relevance of the neuropathogenicity of SARS-CoV-2 and to
                      elucidate a possible impact of SARS-CoV-2 infection on
                      common neurological disease, such as Alzheimer’s,
                      Parkinson’s disease or multiple sclerosis.},
      cin          = {INM-3},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-3-20090406},
      pnm          = {899 - ohne Topic (POF4-899)},
      pid          = {G:(DE-HGF)POF4-899},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {32691236},
      UT           = {WOS:000550621700002},
      doi          = {10.1007/s00415-020-10067-3},
      url          = {https://juser.fz-juelich.de/record/878125},
}