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@ARTICLE{Choi:878145,
      author       = {Choi, Chang-Hoon and Stegmayr, Carina and Shymanskaya,
                      Aliaksandra and Worthoff, Wieland A. and da Silva, Nuno A.
                      and Felder, Jörg and Langen, Karl-Josef and Shah, N. J.},
      title        = {{A}n in vivo multimodal feasibility study in a rat brain
                      tumour model using flexible multinuclear {MR} and {PET}
                      systems},
      journal      = {EJNMMI Physics},
      volume       = {7},
      number       = {1},
      issn         = {2197-7364},
      address      = {Heidelberg},
      publisher    = {Springer Open},
      reportid     = {FZJ-2020-02658},
      pages        = {50},
      year         = {2020},
      abstract     = {BackgroundIn addition to the structural information
                      afforded by 1H MRI, the use of X-nuclei, such as sodium-23
                      (23Na) or phosphorus-31 (31P), offers important
                      complementary information concerning physiological and
                      biochemical parameters. By then combining this technique
                      with PET, which provides valuable insight into a wide range
                      of metabolic and molecular processes by using of a variety
                      of radioactive tracers, the scope of medical imaging and
                      diagnostics can be significantly increased. While the use of
                      multimodal imaging is undoubtedly advantageous, identifying
                      the optimal combination of these parameters to diagnose a
                      specific dysfunction is very important and is advanced by
                      the use of sophisticated imaging techniques in specific
                      animal models.MethodsIn this pilot study, rats with
                      intracerebral 9L gliosarcomas were used to explore a
                      combination of sequential multinuclear MRI using a
                      sophisticated switchable coil set in a small animal 9.4 T
                      MRI scanner and, subsequently, a small animal PET with the
                      tumour tracer O-(2-[18F]-fluoroethyl)-L-tyrosine ([18F]FET).
                      This made it possible for in vivo multinuclear MR-PET
                      experiments to be conducted without compromising the
                      performance of either multinuclear MR or
                      PET.ResultsHigh-quality in vivo images and spectra including
                      high-resolution 1H imaging, 23Na-weighted imaging, detection
                      of 31P metabolites and [18F]FET uptake were obtained,
                      allowing the characterisation of tumour tissues in
                      comparison to a healthy brain. It has been reported in the
                      literature that these parameters are useful in the
                      identification of the genetic profile of gliomas,
                      particularly concerning the mutation of the isocitrate
                      hydrogenase gene, which is highly relevant for treatment
                      strategy.ConclusionsThe combination of multinuclear MR and
                      PET in, for example, brain tumour models with specific
                      genetic mutations will enable the physiological background
                      of signal alterations to be explored and the identification
                      of the optimal combination of imaging parameters for the
                      non-invasive characterisation of the molecular profile of
                      tumours.},
      cin          = {INM-4 / INM-11 / JARA-BRAIN},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-4-20090406 / I:(DE-Juel1)INM-11-20170113 /
                      I:(DE-Juel1)VDB1046},
      pnm          = {573 - Neuroimaging (POF3-573)},
      pid          = {G:(DE-HGF)POF3-573},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:32728773},
      UT           = {WOS:000554694600001},
      doi          = {10.1186/s40658-020-00319-6},
      url          = {https://juser.fz-juelich.de/record/878145},
}