000878189 001__ 878189
000878189 005__ 20221029130703.0
000878189 0247_ $$2doi$$a10.1016/j.neuroimage.2020.117160
000878189 0247_ $$2ISSN$$a1053-8119
000878189 0247_ $$2ISSN$$a1095-9572
000878189 0247_ $$2Handle$$a2128/25422
000878189 0247_ $$2altmetric$$aaltmetric:86145470
000878189 0247_ $$2pmid$$apmid:32679251
000878189 0247_ $$2WOS$$aWOS:000600795000025
000878189 037__ $$aFZJ-2020-02677
000878189 082__ $$a610
000878189 1001_ $$0P:(DE-Juel1)144215$$aMauler, Jörg$$b0$$eCorresponding author
000878189 245__ $$aBolus infusion scheme for the adjustment of steady state [11C]Flumazenil levels in the grey matter and in the blood plasma for neuroreceptor imaging
000878189 260__ $$aOrlando, Fla.$$bAcademic Press$$c2020
000878189 3367_ $$2DRIVER$$aarticle
000878189 3367_ $$2DataCite$$aOutput Types/Journal article
000878189 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1666966319_10383
000878189 3367_ $$2BibTeX$$aARTICLE
000878189 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000878189 3367_ $$00$$2EndNote$$aJournal Article
000878189 520__ $$aThe use of hybrid PET/MR imaging facilitates the simultaneous investigation of challenge-related changes in ligand binding to neuroreceptors using PET, while concurrently measuring neuroactivation or blood flow with MRI. Having attained a steady state of the PET radiotracer using a bolus-infusion protocol, it is possible to observe alterations in ligand neuroreceptor binding through changes in distribution volumes. Here, we present an iterative procedure for establishing an administration scheme to obtain steady state [11C]flumazenil concentrations in grey matter in the human brain. In order to achieve a steady state in the shortest possible time, the bolus infusion ratio from a previous examination was adapted to fit the subsequent examination. 17 male volunteers were included in the study. Boli and infusions with different weightings were given to the subjects and were characterised by values from 74 ​min down to 42 ​min. Metabolite analysis was used to ascertain the value of unmetabolised flumazenil in the plasma, and PET imaging was used to assess its binding in the grey matter. The flumazenil time-activity curves (TACs) in the brain were decomposed into activity contributions from pure grey and white matter and analysed for 12 ​vol of interest (VOIs). The curves highlighted a large variability in metabolic rates between the subjects, with  ​= ​54.3 ​min being a reliable value to provide flumazenil equilibrium conditions in the majority of the VOIs and cases. The distribution volume of flumazenil in all 12 VOIs was determined.
000878189 536__ $$0G:(DE-HGF)POF3-573$$a573 - Neuroimaging (POF3-573)$$cPOF3-573$$fPOF III$$x0
000878189 588__ $$aDataset connected to CrossRef
000878189 7001_ $$0P:(DE-Juel1)132315$$aHeinzel, Alexander$$b1$$ufzj
000878189 7001_ $$0P:(DE-Juel1)138474$$aMatusch, Andreas$$b2$$ufzj
000878189 7001_ $$0P:(DE-Juel1)131768$$aHerzog, Hans$$b3$$ufzj
000878189 7001_ $$0P:(DE-Juel1)131781$$aNeuner, Irene$$b4$$ufzj
000878189 7001_ $$0P:(DE-Juel1)131791$$aScheins, Jürgen$$b5$$ufzj
000878189 7001_ $$0P:(DE-HGF)0$$aWyss, Christine$$b6
000878189 7001_ $$0P:(DE-Juel1)131757$$aDammers, Jürgen$$b7$$ufzj
000878189 7001_ $$0P:(DE-Juel1)131831$$aLang, Markus$$b8$$ufzj
000878189 7001_ $$0P:(DE-Juel1)131818$$aErmert, Johannes$$b9$$ufzj
000878189 7001_ $$0P:(DE-Juel1)166419$$aNeumaier, Bernd$$b10$$ufzj
000878189 7001_ $$0P:(DE-Juel1)131777$$aLangen, Karl-Josef$$b11
000878189 7001_ $$0P:(DE-Juel1)131794$$aShah, N. Jon$$b12$$ufzj
000878189 773__ $$0PERI:(DE-600)1471418-8$$a10.1016/j.neuroimage.2020.117160$$gVol. 221, p. 117160 -$$p117160 -$$tNeuroImage$$v221$$x1053-8119$$y2020
000878189 8564_ $$uhttps://juser.fz-juelich.de/record/878189/files/Invoice_OAD0000056812.pdf
000878189 8564_ $$uhttps://juser.fz-juelich.de/record/878189/files/Bolus%20infusion%20scheme%20for%20the%20adjustment%20of%20steady%20state%20%5B11C%5DFlumazenil%20levels%20in%20the%20grey%20matter%20and%20in%20the%20blood%20plasma%20for%20neuroreceptor%20imaging.pdf$$yOpenAccess
000878189 8564_ $$uhttps://juser.fz-juelich.de/record/878189/files/Invoice_OAD0000056812.pdf?subformat=pdfa$$xpdfa
000878189 8767_ $$8OAD0000056812$$92020-07-10$$d2020-07-10$$eAPC$$jZahlung erfolgt
000878189 909CO $$ooai:juser.fz-juelich.de:878189$$pdnbdelivery$$popenCost$$pVDB$$pdriver$$pOpenAPC$$popen_access$$popenaire
000878189 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)144215$$aForschungszentrum Jülich$$b0$$kFZJ
000878189 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)132315$$aForschungszentrum Jülich$$b1$$kFZJ
000878189 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)138474$$aForschungszentrum Jülich$$b2$$kFZJ
000878189 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)131768$$aForschungszentrum Jülich$$b3$$kFZJ
000878189 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)131781$$aForschungszentrum Jülich$$b4$$kFZJ
000878189 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)131791$$aForschungszentrum Jülich$$b5$$kFZJ
000878189 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)131757$$aForschungszentrum Jülich$$b7$$kFZJ
000878189 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)131831$$aForschungszentrum Jülich$$b8$$kFZJ
000878189 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)131818$$aForschungszentrum Jülich$$b9$$kFZJ
000878189 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)166419$$aForschungszentrum Jülich$$b10$$kFZJ
000878189 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)131777$$aForschungszentrum Jülich$$b11$$kFZJ
000878189 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)131794$$aForschungszentrum Jülich$$b12$$kFZJ
000878189 9131_ $$0G:(DE-HGF)POF3-573$$1G:(DE-HGF)POF3-570$$2G:(DE-HGF)POF3-500$$3G:(DE-HGF)POF3$$4G:(DE-HGF)POF$$aDE-HGF$$bKey Technologies$$lDecoding the Human Brain$$vNeuroimaging$$x0
000878189 9141_ $$y2020
000878189 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS$$d2020-01-03
000878189 915__ $$0StatID:(DE-HGF)0160$$2StatID$$aDBCoverage$$bEssential Science Indicators$$d2020-01-03
000878189 915__ $$0StatID:(DE-HGF)1030$$2StatID$$aDBCoverage$$bCurrent Contents - Life Sciences$$d2020-01-03
000878189 915__ $$0StatID:(DE-HGF)1190$$2StatID$$aDBCoverage$$bBiological Abstracts$$d2020-01-03
000878189 915__ $$0StatID:(DE-HGF)0600$$2StatID$$aDBCoverage$$bEbsco Academic Search$$d2020-01-03
000878189 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bNEUROIMAGE : 2018$$d2020-01-03
000878189 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection$$d2020-01-03
000878189 915__ $$0StatID:(DE-HGF)0110$$2StatID$$aWoS$$bScience Citation Index$$d2020-01-03
000878189 915__ $$0StatID:(DE-HGF)0111$$2StatID$$aWoS$$bScience Citation Index Expanded$$d2020-01-03
000878189 915__ $$0StatID:(DE-HGF)0510$$2StatID$$aOpenAccess
000878189 915__ $$0StatID:(DE-HGF)0030$$2StatID$$aPeer Review$$bASC$$d2020-01-03
000878189 915__ $$0StatID:(DE-HGF)9905$$2StatID$$aIF >= 5$$bNEUROIMAGE : 2018$$d2020-01-03
000878189 915__ $$0StatID:(DE-HGF)0310$$2StatID$$aDBCoverage$$bNCBI Molecular Biology Database$$d2020-01-03
000878189 915__ $$0StatID:(DE-HGF)1050$$2StatID$$aDBCoverage$$bBIOSIS Previews$$d2020-01-03
000878189 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline$$d2020-01-03
000878189 915__ $$0LIC:(DE-HGF)CCBY4$$2HGFVOC$$aCreative Commons Attribution CC BY 4.0
000878189 915__ $$0StatID:(DE-HGF)0420$$2StatID$$aNationallizenz$$d2020-01-03$$wger
000878189 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bClarivate Analytics Master Journal List$$d2020-01-03
000878189 9201_ $$0I:(DE-Juel1)INM-4-20090406$$kINM-4$$lPhysik der Medizinischen Bildgebung$$x0
000878189 9201_ $$0I:(DE-Juel1)INM-11-20170113$$kINM-11$$lJara-Institut Quantum Information$$x1
000878189 9201_ $$0I:(DE-Juel1)VDB1046$$kJARA-BRAIN$$lJülich-Aachen Research Alliance - Translational Brain Medicine$$x2
000878189 9201_ $$0I:(DE-Juel1)INM-5-20090406$$kINM-5$$lNuklearchemie$$x3
000878189 9201_ $$0I:(DE-Juel1)INM-2-20090406$$kINM-2$$lMolekulare Organisation des Gehirns$$x4
000878189 980__ $$ajournal
000878189 980__ $$aVDB
000878189 980__ $$aI:(DE-Juel1)INM-4-20090406
000878189 980__ $$aI:(DE-Juel1)INM-11-20170113
000878189 980__ $$aI:(DE-Juel1)VDB1046
000878189 980__ $$aI:(DE-Juel1)INM-5-20090406
000878189 980__ $$aI:(DE-Juel1)INM-2-20090406
000878189 980__ $$aAPC
000878189 980__ $$aUNRESTRICTED
000878189 9801_ $$aAPC
000878189 9801_ $$aFullTexts