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000878237 041__ $$aGerman
000878237 088__ $$2JUEL$$aJuel-4425
000878237 1001_ $$0P:(DE-Juel1)132740$$aHumpert, Swen$$b0$$eCorresponding author$$gmale$$ufzj
000878237 245__ $$aEntwicklung von Kupplungsmethoden mit neuen Markierungsbausteinen zur Synthese $^{18}$F-markierter PSMA-selektiver Liganden und argininreicher all-D Peptide$$f- 2020-04-30
000878237 260__ $$aJülich$$bForschungszentrum Jülich GmbH Zentralbibliothek, Verlag$$c2020
000878237 300__ $$aVII, 160 S.
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000878237 4900_ $$aBerichte des Forschungszentrums Jülich$$v4425
000878237 502__ $$aUniversität Köln, Diss., 2020$$bDissertation$$cUniversität Köln$$d2020
000878237 520__ $$aPositron emission tomography (PET) is an indispensable tool in clinical research and diagnostics for the visualization of physiological and pathophysiological processes at themolecular level $\textit{in vivo}$. For different clinical examinations, PET requires radiolabeled, tailormade molecules, so called radiotracers, specifically targeting selected molecular structures. The development and efficient production of these tracers is therefore an essential task in PETresearch. Direct radiolabeling approaches with $^{18}$F, one of the most suitable radionuclides for PET, require harsh reaction conditions and are often not applicable for sensitive biomolecules. However, indirect methods using radiolabeled building blocks are well suited as alternatives although they are more time consuming due to multi step syntheses and thus less effective. The aim of this work was the further development and application of novel indirect radiolabeling methods for peptides. Accordingly, two different peptides have been used for radiolabeling. Radiolabeled PSMA-selective ligands and arginine-rich, fully D-enantiomeric peptides (D3 and RD2) should be prepared in this work. PSMA-selective peptidomimetics are currently being used for the detection of prostate carcinoma and the D-enantiomeric peptides in Alzheimer's research since they potentially enable a causal treatment of this disease which is otherwise not possible so far. For the conjugation of the promising synthon (Z)-2-[$^{18}$F]fluorohex-1-en-1-yl(phenyl)iodoniumtosylate ([$^{18}$F]FHexI$^{+}$), various Pd-catalyzed cross-coupling reactions were first investigated using structurally simple coupling partners. After radiosynthesis of [$^{18}$F]FHexI$^{+}$ under aqueous conditions starting from [$^{18}$F]fluoride, subsequently both, the Sonogashira coupling and the Suzuki coupling reaction were carried out as a one-pot reaction directly in the initial labelling mixture. [...]
000878237 536__ $$0G:(DE-HGF)POF3-573$$a573 - Neuroimaging (POF3-573)$$cPOF3-573$$fPOF III$$x0
000878237 8564_ $$uhttps://juser.fz-juelich.de/record/878237/files/J%C3%BCl_4425.pdf$$yOpenAccess
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000878237 9141_ $$y2020
000878237 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)132740$$aForschungszentrum Jülich$$b0$$kFZJ
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