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@PHDTHESIS{Humpert:878237,
      author       = {Humpert, Swen},
      title        = {{E}ntwicklung von {K}upplungsmethoden mit neuen
                      {M}arkierungsbausteinen zur {S}ynthese $^{18}${F}-markierter
                      {PSMA}-selektiver {L}iganden und argininreicher all-{D}
                      {P}eptide},
      volume       = {4425},
      school       = {Universität Köln},
      type         = {Dissertation},
      address      = {Jülich},
      publisher    = {Forschungszentrum Jülich GmbH Zentralbibliothek, Verlag},
      reportid     = {FZJ-2020-02706, Juel-4425},
      series       = {Berichte des Forschungszentrums Jülich},
      pages        = {VII, 160 S.},
      year         = {2020},
      note         = {Universität Köln, Diss., 2020},
      abstract     = {Positron emission tomography (PET) is an indispensable tool
                      in clinical research and diagnostics for the visualization
                      of physiological and pathophysiological processes at
                      themolecular level $\textit{in vivo}$. For different
                      clinical examinations, PET requires radiolabeled, tailormade
                      molecules, so called radiotracers, specifically targeting
                      selected molecular structures. The development and efficient
                      production of these tracers is therefore an essential task
                      in PETresearch. Direct radiolabeling approaches with
                      $^{18}$F, one of the most suitable radionuclides for PET,
                      require harsh reaction conditions and are often not
                      applicable for sensitive biomolecules. However, indirect
                      methods using radiolabeled building blocks are well suited
                      as alternatives although they are more time consuming due to
                      multi step syntheses and thus less effective. The aim of
                      this work was the further development and application of
                      novel indirect radiolabeling methods for peptides.
                      Accordingly, two different peptides have been used for
                      radiolabeling. Radiolabeled PSMA-selective ligands and
                      arginine-rich, fully D-enantiomeric peptides (D3 and RD2)
                      should be prepared in this work. PSMA-selective
                      peptidomimetics are currently being used for the detection
                      of prostate carcinoma and the D-enantiomeric peptides in
                      Alzheimer's research since they potentially enable a causal
                      treatment of this disease which is otherwise not possible so
                      far. For the conjugation of the promising synthon
                      (Z)-2-[$^{18}$F]fluorohex-1-en-1-yl(phenyl)iodoniumtosylate
                      ([$^{18}$F]FHexI$^{+}$), various Pd-catalyzed cross-coupling
                      reactions were first investigated using structurally simple
                      coupling partners. After radiosynthesis of
                      [$^{18}$F]FHexI$^{+}$ under aqueous conditions starting from
                      [$^{18}$F]fluoride, subsequently both, the Sonogashira
                      coupling and the Suzuki coupling reaction were carried out
                      as a one-pot reaction directly in the initial labelling
                      mixture. [...]},
      cin          = {INM-5},
      cid          = {I:(DE-Juel1)INM-5-20090406},
      pnm          = {573 - Neuroimaging (POF3-573)},
      pid          = {G:(DE-HGF)POF3-573},
      typ          = {PUB:(DE-HGF)3 / PUB:(DE-HGF)11},
      url          = {https://juser.fz-juelich.de/record/878237},
}