TY  - JOUR
AU  - Zlatopolskiy, B. D.
AU  - Endepols, H.
AU  - Krasikova, R. N.
AU  - Fedorova, O. S.
AU  - Ermert, J.
AU  - Neumaier, B.
TI  - 11C- and 18F-labelled tryptophans as PET-tracers for imaging of altered tryptophan metabolism in age-associated disorders
JO  - Russian chemical reviews
VL  - 89
IS  - 9
SN  - 1468-4837
CY  - [Letchworth]
PB  - Turpion
M1  - FZJ-2020-02797
SP  - 879 - 896
PY  - 2020
AB  - The ageing of the world's population is the result of increased life expectancy observed in almost all countries throughout the world. Consequently, a rising tide of ageing-associated disorders, like cancer and neurodegenerative diseases, represents oneof the main global challenges of the 21st century. The ability of mankind to overcome these challenges is directly dependent on the capability to develop novel methods for therapy and diagnosis of age-associated diseases. One hallmark of age-relatedpathologies is an altered tryptophan metabolism. Numerous pathological processes including neurodegenerative and neurological diseases like epilepsy, Parkinson's and Alzheimer's diseases, cancer and diabetes exhibit marked changes intryptophan metabolism. Visualization of key processes of tryptophan metabolic pathways, especially using positron emission tomography (PET) and related hybrid methods like PET/CT and PET/MRI, can be exploited to early detect theaforementioned disorders with considerable accuracy, allowing appropriate and timely treatment of patients. Here we review the published 11C- and 18F-labelled tryptophans with respect to the production and also preclinical and clinical evaluation asPET-tracers for visualization of different branches of tryptophan metabolism.The bibliography includes 159 references.
LB  - PUB:(DE-HGF)16
UR  - <Go to ISI:>//WOS:000557617800001
DO  - DOI:10.1070/RCR4954
UR  - https://juser.fz-juelich.de/record/878350
ER  -