% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Zlatopolskiy:878350,
      author       = {Zlatopolskiy, B. D. and Endepols, H. and Krasikova, R. N.
                      and Fedorova, O. S. and Ermert, J. and Neumaier, B.},
      title        = {11{C}- and 18{F}-labelled tryptophans as {PET}-tracers for
                      imaging of altered tryptophan metabolism in age-associated
                      disorders},
      journal      = {Russian chemical reviews},
      volume       = {89},
      number       = {9},
      issn         = {1468-4837},
      address      = {[Letchworth]},
      publisher    = {Turpion},
      reportid     = {FZJ-2020-02797},
      pages        = {879 - 896},
      year         = {2020},
      abstract     = {The ageing of the world's population is the result of
                      increased life expectancy observed in almost all countries
                      throughout the world. Consequently, a rising tide of
                      ageing-associated disorders, like cancer and
                      neurodegenerative diseases, represents oneof the main global
                      challenges of the 21st century. The ability of mankind to
                      overcome these challenges is directly dependent on the
                      capability to develop novel methods for therapy and
                      diagnosis of age-associated diseases. One hallmark of
                      age-relatedpathologies is an altered tryptophan metabolism.
                      Numerous pathological processes including neurodegenerative
                      and neurological diseases like epilepsy, Parkinson's and
                      Alzheimer's diseases, cancer and diabetes exhibit marked
                      changes intryptophan metabolism. Visualization of key
                      processes of tryptophan metabolic pathways, especially using
                      positron emission tomography (PET) and related hybrid
                      methods like PET/CT and PET/MRI, can be exploited to early
                      detect theaforementioned disorders with considerable
                      accuracy, allowing appropriate and timely treatment of
                      patients. Here we review the published 11C- and 18F-labelled
                      tryptophans with respect to the production and also
                      preclinical and clinical evaluation asPET-tracers for
                      visualization of different branches of tryptophan
                      metabolism.The bibliography includes 159 references.},
      cin          = {INM-5},
      ddc          = {540},
      cid          = {I:(DE-Juel1)INM-5-20090406},
      pnm          = {573 - Neuroimaging (POF3-573)},
      pid          = {G:(DE-HGF)POF3-573},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000557617800001},
      doi          = {10.1070/RCR4954},
      url          = {https://juser.fz-juelich.de/record/878350},
}