TY  - JOUR
AU  - Breisch, Marina
AU  - Loza, Kateryna
AU  - Pappert, Kevin
AU  - Rostek, Alexander
AU  - Rurainsky, Christian
AU  - Tschulik, Kristina
AU  - Heggen, Marc
AU  - Epple, Matthias
AU  - Tiller, Jörg C
AU  - Schildhauer, Thomas A
AU  - Köller, Manfred
AU  - Sengstock, Christina
TI  - Enhanced dissolution of silver nanoparticles in a physical mixture with platinum nanoparticles based on the sacrificial anode effectE
JO  - Nanotechnology
VL  - 31
IS  - 5
SN  - 1361-6528
CY  - Bristol
PB  - IOP Publ.
M1  - FZJ-2020-02829
SP  - 055703 -
PY  - 2020
AB  - A strategy to reduce implant-related infections is the inhibition of the initial bacterial implant colonization by biomaterials containing silver (Ag). The antimicrobial efficacy of such biomaterials can be increased by surface enhancement (nanosilver) or by creating a sacrificial anode system for Ag. Such a system will lead to an electrochemically driven enhanced Ag ion release due to the presence of a more noble metal. Here we combined the enlarged surface of nanoparticles (NP) with a possible sacrificial anode effect for Ag induced by the presence of the electrochemically more noble platinum (Pt) in physical mixtures of Ag NP and Pt NP dispersions. These Ag NP/Pt NP mixtures were compared to the same amounts of pure Ag NP in terms of cell biological responses, i.e. the antimicrobial activity against Staphylococcus aureus and Escherichia coli as well as the viability of human mesenchymal stem cells (hMSC). In addition, Ag NP was analyzed by ultraviolet–visible (UV–vis) spectroscopy, cyclic voltammetry, and atomic absorption spectroscopy. It was found that the dissolution rate of Ag NP was enhanced in the presence of Pt NP within the physical mixture compared to a dispersion of pure Ag NP. Dissolution experiments revealed a fourfold increased Ag ion release from physical mixtures due to enhanced electrochemical activity, which resulted in a significantly increased toxicity towards both bacteria and hMSC. Thus, our results provide evidence for an underlying sacrificial anode mechanism induced by the presence of Pt NP within physical mixtures with Ag NP. Such physical mixtures have a high potential for various applications, for example as antimicrobial implant coatings in the biomedicine or as bactericidal systems for water and surface purification in the technical area.
LB  - PUB:(DE-HGF)16
C6  - pmid:31618711
UR  - <Go to ISI:>//WOS:000494489200001
DO  - DOI:10.1088/1361-6528/ab4e48
UR  - https://juser.fz-juelich.de/record/878393
ER  -