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@ARTICLE{Breisch:878393,
      author       = {Breisch, Marina and Loza, Kateryna and Pappert, Kevin and
                      Rostek, Alexander and Rurainsky, Christian and Tschulik,
                      Kristina and Heggen, Marc and Epple, Matthias and Tiller,
                      Jörg C and Schildhauer, Thomas A and Köller, Manfred and
                      Sengstock, Christina},
      title        = {{E}nhanced dissolution of silver nanoparticles in a
                      physical mixture with platinum nanoparticles based on the
                      sacrificial anode effect{E}},
      journal      = {Nanotechnology},
      volume       = {31},
      number       = {5},
      issn         = {1361-6528},
      address      = {Bristol},
      publisher    = {IOP Publ.},
      reportid     = {FZJ-2020-02829},
      pages        = {055703 -},
      year         = {2020},
      abstract     = {A strategy to reduce implant-related infections is the
                      inhibition of the initial bacterial implant colonization by
                      biomaterials containing silver (Ag). The antimicrobial
                      efficacy of such biomaterials can be increased by surface
                      enhancement (nanosilver) or by creating a sacrificial anode
                      system for Ag. Such a system will lead to an
                      electrochemically driven enhanced Ag ion release due to the
                      presence of a more noble metal. Here we combined the
                      enlarged surface of nanoparticles (NP) with a possible
                      sacrificial anode effect for Ag induced by the presence of
                      the electrochemically more noble platinum (Pt) in physical
                      mixtures of Ag NP and Pt NP dispersions. These Ag NP/Pt NP
                      mixtures were compared to the same amounts of pure Ag NP in
                      terms of cell biological responses, i.e. the antimicrobial
                      activity against Staphylococcus aureus and Escherichia coli
                      as well as the viability of human mesenchymal stem cells
                      (hMSC). In addition, Ag NP was analyzed by
                      ultraviolet–visible (UV–vis) spectroscopy, cyclic
                      voltammetry, and atomic absorption spectroscopy. It was
                      found that the dissolution rate of Ag NP was enhanced in the
                      presence of Pt NP within the physical mixture compared to a
                      dispersion of pure Ag NP. Dissolution experiments revealed a
                      fourfold increased Ag ion release from physical mixtures due
                      to enhanced electrochemical activity, which resulted in a
                      significantly increased toxicity towards both bacteria and
                      hMSC. Thus, our results provide evidence for an underlying
                      sacrificial anode mechanism induced by the presence of Pt NP
                      within physical mixtures with Ag NP. Such physical mixtures
                      have a high potential for various applications, for example
                      as antimicrobial implant coatings in the biomedicine or as
                      bactericidal systems for water and surface purification in
                      the technical area.},
      cin          = {ER-C-1},
      ddc          = {530},
      cid          = {I:(DE-Juel1)ER-C-1-20170209},
      pnm          = {143 - Controlling Configuration-Based Phenomena (POF3-143)
                      / DFG project 286659497 - Bimetallische Nanopartikel der
                      Platinmetalle (Ru, Rh, Pd, Os, Ir, Pt) und des Silbers:
                      Synthese, Mikrostruktur und biologische Wirkung (286659497)},
      pid          = {G:(DE-HGF)POF3-143 / G:(GEPRIS)286659497},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:31618711},
      UT           = {WOS:000494489200001},
      doi          = {10.1088/1361-6528/ab4e48},
      url          = {https://juser.fz-juelich.de/record/878393},
}