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@ARTICLE{Lehmann:878460,
      author       = {Lehmann, Helmar C. and Wunderlich, Gilbert and Fink, Gereon
                      R. and Sommer, Claudia},
      title        = {{D}iagnosis of peripheral neuropathy},
      journal      = {Neurological research and practice},
      volume       = {2},
      number       = {1},
      issn         = {2524-3489},
      address      = {[London]},
      publisher    = {BioMed Central},
      reportid     = {FZJ-2020-02865},
      pages        = {20},
      year         = {2020},
      abstract     = {IntroductionPeripheral neuropathy represents a spectrum of
                      diseases with different etiologies. The most common causes
                      are diabetes, exposure to toxic substances including alcohol
                      and chemotherapeutics, immune-mediated conditions, and gene
                      mutations. A thorough workup including clinical history and
                      examination, nerve conduction studies, and comprehensive
                      laboratory tests is warranted to identify treatable
                      causes.First stepsThe variability of symptoms allows
                      distinguishing characteristic clinical phenotypes of
                      peripheral neuropathy that should be recognized in order to
                      stratify the diagnostic workup accordingly. Nerve conduction
                      studies are essential to determine the phenotype (axonal
                      versus demyelinating) and severity. Laboratory tests,
                      including genetic testing, CSF examination, nerve imaging,
                      and nerve biopsy, represent additional clinical tests that
                      can be useful in specific clinical scenarios.CommentsWe
                      propose a flow chart based on five common basic clinical
                      patterns of peripheral neuropathy. Based on these five
                      clinical phenotypes, we suggest differential diagnostic
                      pathways in order to establish the underlying
                      cause.ConclusionsThe recognition of characteristic clinical
                      phenotypes combined with nerve conduction studies allows
                      pursuing subsequent diagnostic pathways that incorporate
                      nerve conduction studies and additional diagnostic tests.
                      This two-tiered approach promises higher yield and better
                      cost-effectiveness in the diagnostic workup in patients with
                      peripheral neuropathy.},
      cin          = {INM-3},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-3-20090406},
      pnm          = {572 - (Dys-)function and Plasticity (POF3-572)},
      pid          = {G:(DE-HGF)POF3-572},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {33324924},
      UT           = {WOS:001044706800001},
      doi          = {10.1186/s42466-020-00064-2},
      url          = {https://juser.fz-juelich.de/record/878460},
}