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000878506 1001_ $$0P:(DE-Juel1)167223$$aPlachti, Anna$$b0$$eCorresponding author$$ufzj
000878506 245__ $$aHippocampus co-atrophy pattern in dementia deviates from covariance patterns across the lifespan
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000878506 520__ $$aThe hippocampus is a plastic region and highly susceptible to ageing and dementia. Previous studies explicitly imposed a priori models of hippocampus when investigating ageing and dementia-specific atrophy but led to inconsistent results. Consequently, the basic question of whether macrostructural changes follow a cytoarchitectonic or functional organization across the adult lifespan and in age-related neurodegenerative disease remained open. The aim of this cross-sectional study was to identify the spatial pattern of hippocampus differentiation based on structural covariance with a data-driven approach across structural MRI data of large cohorts (n = 2594). We examined the pattern of structural covariance of hippocampus voxels in young, middle-aged, elderly, mild cognitive impairment and dementia disease samples by applying a clustering algorithm revealing differentiation in structural covariance within the hippocampus. In all the healthy and in the mild cognitive impaired participants, the hippocampus was robustly divided into anterior, lateral and medial subregions reminiscent of cytoarchitectonic division. In contrast, in dementia patients, the pattern of subdivision was closer to known functional differentiation into an anterior, body and tail subregions. These results not only contribute to a better understanding of co-plasticity and co-atrophy in the hippocampus across the lifespan and in dementia, but also provide robust data-driven spatial representations (i.e. maps) for structural studies.
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000878506 7001_ $$0P:(DE-Juel1)171719$$aKharabian, Shahrzad$$b1$$ufzj
000878506 7001_ $$0P:(DE-Juel1)131678$$aEickhoff, Simon B$$b2$$ufzj
000878506 7001_ $$0P:(DE-Juel1)178767$$aMaleki Balajoo, Somayeh$$b3$$ufzj
000878506 7001_ $$0P:(DE-Juel1)131684$$aHoffstaedter, Felix$$b4$$ufzj
000878506 7001_ $$0P:(DE-Juel1)161460$$aVarikuti, Deepthi$$b5
000878506 7001_ $$0P:(DE-Juel1)145386$$aJockwitz, Christiane$$b6$$ufzj
000878506 7001_ $$0P:(DE-Juel1)131675$$aCaspers, Svenja$$b7$$ufzj
000878506 7001_ $$0P:(DE-Juel1)131631$$aAmunts, Katrin$$b8$$ufzj
000878506 7001_ $$0P:(DE-Juel1)161225$$aGenon, Sarah$$b9$$ufzj
000878506 773__ $$0PERI:(DE-600)1474117-9$$a10.1093/brain/awaa222$$gVol. 143, no. 9, p. 2788 - 2802$$n9$$p2788 - 2802$$tBrain$$v143$$x1460-2156$$y2020
000878506 8564_ $$uhttps://juser.fz-juelich.de/record/878506/files/reprint_13715899.pdf
000878506 8564_ $$uhttps://juser.fz-juelich.de/record/878506/files/Hippocampus%20co-atrophy%20pattern%20in%20dementiadeviates%20from%20covariance%20patterns%20across%20thelifespan.pdf$$yOpenAccess
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