TY  - JOUR
AU  - Plachti, Anna
AU  - Kharabian, Shahrzad
AU  - Eickhoff, Simon B
AU  - Maleki Balajoo, Somayeh
AU  - Hoffstaedter, Felix
AU  - Varikuti, Deepthi
AU  - Jockwitz, Christiane
AU  - Caspers, Svenja
AU  - Amunts, Katrin
AU  - Genon, Sarah
TI  - Hippocampus co-atrophy pattern in dementia deviates from covariance patterns across the lifespan
JO  - Brain
VL  - 143
IS  - 9
SN  - 1460-2156
CY  - Oxford
PB  - Oxford Univ. Press
M1  - FZJ-2020-02885
SP  - 2788 - 2802
PY  - 2020
AB  - The hippocampus is a plastic region and highly susceptible to ageing and dementia. Previous studies explicitly imposed a priori models of hippocampus when investigating ageing and dementia-specific atrophy but led to inconsistent results. Consequently, the basic question of whether macrostructural changes follow a cytoarchitectonic or functional organization across the adult lifespan and in age-related neurodegenerative disease remained open. The aim of this cross-sectional study was to identify the spatial pattern of hippocampus differentiation based on structural covariance with a data-driven approach across structural MRI data of large cohorts (n = 2594). We examined the pattern of structural covariance of hippocampus voxels in young, middle-aged, elderly, mild cognitive impairment and dementia disease samples by applying a clustering algorithm revealing differentiation in structural covariance within the hippocampus. In all the healthy and in the mild cognitive impaired participants, the hippocampus was robustly divided into anterior, lateral and medial subregions reminiscent of cytoarchitectonic division. In contrast, in dementia patients, the pattern of subdivision was closer to known functional differentiation into an anterior, body and tail subregions. These results not only contribute to a better understanding of co-plasticity and co-atrophy in the hippocampus across the lifespan and in dementia, but also provide robust data-driven spatial representations (i.e. maps) for structural studies.
LB  - PUB:(DE-HGF)16
C6  - pmid:32851402
UR  - <Go to ISI:>//WOS:000607095300028
DO  - DOI:10.1093/brain/awaa222
UR  - https://juser.fz-juelich.de/record/878506
ER  -