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@ARTICLE{Plachti:878506,
      author       = {Plachti, Anna and Kharabian, Shahrzad and Eickhoff, Simon B
                      and Maleki Balajoo, Somayeh and Hoffstaedter, Felix and
                      Varikuti, Deepthi and Jockwitz, Christiane and Caspers,
                      Svenja and Amunts, Katrin and Genon, Sarah},
      title        = {{H}ippocampus co-atrophy pattern in dementia deviates from
                      covariance patterns across the lifespan},
      journal      = {Brain},
      volume       = {143},
      number       = {9},
      issn         = {1460-2156},
      address      = {Oxford},
      publisher    = {Oxford Univ. Press},
      reportid     = {FZJ-2020-02885},
      pages        = {2788 - 2802},
      year         = {2020},
      abstract     = {The hippocampus is a plastic region and highly susceptible
                      to ageing and dementia. Previous studies explicitly imposed
                      a priori models of hippocampus when investigating ageing and
                      dementia-specific atrophy but led to inconsistent results.
                      Consequently, the basic question of whether macrostructural
                      changes follow a cytoarchitectonic or functional
                      organization across the adult lifespan and in age-related
                      neurodegenerative disease remained open. The aim of this
                      cross-sectional study was to identify the spatial pattern of
                      hippocampus differentiation based on structural covariance
                      with a data-driven approach across structural MRI data of
                      large cohorts (n = 2594). We examined the pattern of
                      structural covariance of hippocampus voxels in young,
                      middle-aged, elderly, mild cognitive impairment and dementia
                      disease samples by applying a clustering algorithm revealing
                      differentiation in structural covariance within the
                      hippocampus. In all the healthy and in the mild cognitive
                      impaired participants, the hippocampus was robustly divided
                      into anterior, lateral and medial subregions reminiscent of
                      cytoarchitectonic division. In contrast, in dementia
                      patients, the pattern of subdivision was closer to known
                      functional differentiation into an anterior, body and tail
                      subregions. These results not only contribute to a better
                      understanding of co-plasticity and co-atrophy in the
                      hippocampus across the lifespan and in dementia, but also
                      provide robust data-driven spatial representations (i.e.
                      maps) for structural studies.},
      cin          = {INM-7 / INM-1},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-7-20090406 / I:(DE-Juel1)INM-1-20090406},
      pnm          = {572 - (Dys-)function and Plasticity (POF3-572) / 571 -
                      Connectivity and Activity (POF3-571) / HBP SGA2 - Human
                      Brain Project Specific Grant Agreement 2 (785907) / SMHB -
                      Supercomputing and Modelling for the Human Brain
                      (HGF-SMHB-2013-2017)},
      pid          = {G:(DE-HGF)POF3-572 / G:(DE-HGF)POF3-571 /
                      G:(EU-Grant)785907 / G:(DE-Juel1)HGF-SMHB-2013-2017},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:32851402},
      UT           = {WOS:000607095300028},
      doi          = {10.1093/brain/awaa222},
      url          = {https://juser.fz-juelich.de/record/878506},
}