%0 Journal Article
%A Craig, Austin
%A Kolks, Niklas
%A Urusova, Elizaveta
%A Zischler, Johannes
%A Brugger, Melanie
%A Endepols, Heike
%A Neumaier, Bernd
%A Zlatopolskiy, Boris D.
%T Preparation of labeled aromatic amino acids via late-stage 18 F-fluorination of chiral nickel and copper complexes
%J Chemical communications
%V 56
%N 66
%@ 1364-548X
%C Cambridge
%I Soc.
%M FZJ-2020-02891
%P 9505 - 9508
%D 2020
%X A general protocol for the preparation of 18F-labeled AAAs and α-methyl-AAAs applying alcohol-enhanced Cu-mediated radiofluorination of Bpin-substituted chiral complexes using Ni/Cu-BPX templates as double protecting groups is reported. The chiral auxiliaries are easily accessible from commercially available starting materials in a few synthetic steps. The versatility of the method was demonstrated by the high-yielding preparation of a series of [18F]F-AAAs and the successful implementation of the protocol into automated radiosynthesis modules.
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:32686800
%U <Go to ISI:>//WOS:000560564400016
%R 10.1039/D0CC02223C
%U https://juser.fz-juelich.de/record/878512