TY  - JOUR
AU  - Craig, Austin
AU  - Kolks, Niklas
AU  - Urusova, Elizaveta
AU  - Zischler, Johannes
AU  - Brugger, Melanie
AU  - Endepols, Heike
AU  - Neumaier, Bernd
AU  - Zlatopolskiy, Boris D.
TI  - Preparation of labeled aromatic amino acids via late-stage 18 F-fluorination of chiral nickel and copper complexes
JO  - Chemical communications
VL  - 56
IS  - 66
SN  - 1364-548X
CY  - Cambridge
PB  - Soc.
M1  - FZJ-2020-02891
SP  - 9505 - 9508
PY  - 2020
AB  - A general protocol for the preparation of 18F-labeled AAAs and α-methyl-AAAs applying alcohol-enhanced Cu-mediated radiofluorination of Bpin-substituted chiral complexes using Ni/Cu-BPX templates as double protecting groups is reported. The chiral auxiliaries are easily accessible from commercially available starting materials in a few synthetic steps. The versatility of the method was demonstrated by the high-yielding preparation of a series of [18F]F-AAAs and the successful implementation of the protocol into automated radiosynthesis modules.
LB  - PUB:(DE-HGF)16
C6  - pmid:32686800
UR  - <Go to ISI:>//WOS:000560564400016
DO  - DOI:10.1039/D0CC02223C
UR  - https://juser.fz-juelich.de/record/878512
ER  -