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024 7 _ |a 10.1039/D0CC02223C
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100 1 _ |a Craig, Austin
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245 _ _ |a Preparation of labeled aromatic amino acids via late-stage 18 F-fluorination of chiral nickel and copper complexes
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520 _ _ |a A general protocol for the preparation of 18F-labeled AAAs and α-methyl-AAAs applying alcohol-enhanced Cu-mediated radiofluorination of Bpin-substituted chiral complexes using Ni/Cu-BPX templates as double protecting groups is reported. The chiral auxiliaries are easily accessible from commercially available starting materials in a few synthetic steps. The versatility of the method was demonstrated by the high-yielding preparation of a series of [18F]F-AAAs and the successful implementation of the protocol into automated radiosynthesis modules.
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700 1 _ |a Zischler, Johannes
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700 1 _ |a Endepols, Heike
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700 1 _ |a Neumaier, Bernd
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700 1 _ |a Zlatopolskiy, Boris D.
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773 _ _ |a 10.1039/D0CC02223C
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