000878602 001__ 878602
000878602 005__ 20220930130249.0
000878602 0247_ $$2doi$$a10.1038/s41594-020-0442-4
000878602 0247_ $$2ISSN$$a1072-8368
000878602 0247_ $$2ISSN$$a1545-9985
000878602 0247_ $$2ISSN$$a1545-9993
000878602 0247_ $$2ISSN$$a2331-365X
000878602 0247_ $$2Handle$$a2128/26817
000878602 0247_ $$2altmetric$$aaltmetric:84051263
000878602 0247_ $$2pmid$$a32541895
000878602 0247_ $$2WOS$$aWOS:000543557100001
000878602 037__ $$aFZJ-2020-02940
000878602 082__ $$a570
000878602 1001_ $$0P:(DE-Juel1)174309$$aRöder, Christine$$b0
000878602 245__ $$aCryo-EM structure of islet amyloid polypeptide fibrils reveals similarities with amyloid-β fibrils
000878602 260__ $$aLondon [u.a.]$$bNature Publishing Group$$c2020
000878602 3367_ $$2DRIVER$$aarticle
000878602 3367_ $$2DataCite$$aOutput Types/Journal article
000878602 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1649835762_25745
000878602 3367_ $$2BibTeX$$aARTICLE
000878602 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000878602 3367_ $$00$$2EndNote$$aJournal Article
000878602 520__ $$aAmyloid deposits consisting of fibrillar islet amyloid polypeptide (IAPP) in pancreatic islets are associated with beta-cell loss and have been implicated in type 2 diabetes (T2D). Here, we applied cryo-EM to reconstruct densities of three dominant IAPP fibril polymorphs, formed in vitro from synthetic human IAPP. An atomic model of the main polymorph, built from a density map of 4.2-Å resolution, reveals two S-shaped, intertwined protofilaments. The segment 21-NNFGAIL-27, essential for IAPP amyloidogenicity, forms the protofilament interface together with Tyr37 and the amidated C terminus. The S-fold resembles polymorphs of Alzheimer's disease (AD)-associated amyloid-β (Aβ) fibrils, which might account for the epidemiological link between T2D and AD and reports on IAPP-Aβ cross-seeding in vivo. The results structurally link the early-onset T2D IAPP genetic polymorphism (encoding Ser20Gly) with the AD Arctic mutation (Glu22Gly) of Aβ and support the design of inhibitors and imaging probes for IAPP fibrils.
000878602 536__ $$0G:(DE-HGF)POF3-551$$a551 - Functional Macromolecules and Complexes (POF3-551)$$cPOF3-551$$fPOF III$$x0
000878602 588__ $$aDataset connected to CrossRef
000878602 7001_ $$0P:(DE-Juel1)176456$$aKupreichyk, Tatsiana$$b1$$ufzj
000878602 7001_ $$0P:(DE-Juel1)145165$$aGremer, Lothar$$b2
000878602 7001_ $$0P:(DE-Juel1)178773$$aSchäfer, Luisa U.$$b3
000878602 7001_ $$0P:(DE-Juel1)174468$$aPothula, Karunakar R.$$b4$$ufzj
000878602 7001_ $$00000-0001-6056-5888$$aRavelli, Raimond B. G.$$b5
000878602 7001_ $$0P:(DE-Juel1)132029$$aWillbold, Dieter$$b6
000878602 7001_ $$0P:(DE-Juel1)166306$$aHoyer, Wolfgang$$b7
000878602 7001_ $$0P:(DE-Juel1)132018$$aSchröder, Gunnar F.$$b8$$eCorresponding author
000878602 773__ $$0PERI:(DE-600)2131437-8$$a10.1038/s41594-020-0442-4$$gVol. 27, no. 7, p. 660 - 667$$n7$$p660 - 667$$tNature structural & molecular biology$$v27$$x1545-9985$$y2020
000878602 8564_ $$uhttps://juser.fz-juelich.de/record/878602/files/s41594-020-0442-4-1.pdf$$yRestricted
000878602 8564_ $$uhttps://juser.fz-juelich.de/record/878602/files/Autorenmanuskript_Cryo-EM%20structure%20of%20islet%20amyloid%20polypeptide%20fibrils%20reveals%20similarities%20with%20amyloid-%CE%B2%20fibrils.pdf$$yPublished on 2020-06-15. Available in OpenAccess from 2020-12-15.$$zStatID:(DE-HGF)0510
000878602 8767_ $$82676197792$$92020-08-13$$d2021-05-26$$eColour charges$$jZahlung erfolgt$$zBelegnr. 1200167429
000878602 909CO $$ooai:juser.fz-juelich.de:878602$$popenCost$$pVDB$$pdriver$$pOpenAPC$$popen_access$$popenaire$$pdnbdelivery
000878602 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)174309$$aForschungszentrum Jülich$$b0$$kFZJ
000878602 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)176456$$aForschungszentrum Jülich$$b1$$kFZJ
000878602 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)145165$$aForschungszentrum Jülich$$b2$$kFZJ
000878602 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)178773$$aForschungszentrum Jülich$$b3$$kFZJ
000878602 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)174468$$aForschungszentrum Jülich$$b4$$kFZJ
000878602 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)132029$$aForschungszentrum Jülich$$b6$$kFZJ
000878602 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)166306$$aForschungszentrum Jülich$$b7$$kFZJ
000878602 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)132018$$aForschungszentrum Jülich$$b8$$kFZJ
000878602 9131_ $$0G:(DE-HGF)POF3-551$$1G:(DE-HGF)POF3-550$$2G:(DE-HGF)POF3-500$$3G:(DE-HGF)POF3$$4G:(DE-HGF)POF$$aDE-HGF$$bKey Technologies$$lBioSoft – Fundamentals for future Technologies in the fields of Soft Matter and Life Sciences$$vFunctional Macromolecules and Complexes$$x0
000878602 9141_ $$y2020
000878602 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS$$d2020-01-02
000878602 915__ $$0StatID:(DE-HGF)0160$$2StatID$$aDBCoverage$$bEssential Science Indicators$$d2020-01-02
000878602 915__ $$0StatID:(DE-HGF)1030$$2StatID$$aDBCoverage$$bCurrent Contents - Life Sciences$$d2020-01-02
000878602 915__ $$0StatID:(DE-HGF)1190$$2StatID$$aDBCoverage$$bBiological Abstracts$$d2020-01-02
000878602 915__ $$0StatID:(DE-HGF)0600$$2StatID$$aDBCoverage$$bEbsco Academic Search$$d2020-01-02
000878602 915__ $$0StatID:(DE-HGF)0530$$2StatID$$aEmbargoed OpenAccess
000878602 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bNAT STRUCT MOL BIOL : 2018$$d2020-01-02
000878602 915__ $$0StatID:(DE-HGF)9910$$2StatID$$aIF >= 10$$bNAT STRUCT MOL BIOL : 2018$$d2020-01-02
000878602 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection$$d2020-01-02
000878602 915__ $$0StatID:(DE-HGF)0110$$2StatID$$aWoS$$bScience Citation Index$$d2020-01-02
000878602 915__ $$0StatID:(DE-HGF)0111$$2StatID$$aWoS$$bScience Citation Index Expanded$$d2020-01-02
000878602 915__ $$0StatID:(DE-HGF)0030$$2StatID$$aPeer Review$$bASC$$d2020-01-02
000878602 915__ $$0StatID:(DE-HGF)0310$$2StatID$$aDBCoverage$$bNCBI Molecular Biology Database$$d2020-01-02
000878602 915__ $$0StatID:(DE-HGF)1050$$2StatID$$aDBCoverage$$bBIOSIS Previews$$d2020-01-02
000878602 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline$$d2020-01-02
000878602 915__ $$0StatID:(DE-HGF)0420$$2StatID$$aNationallizenz$$d2020-01-02$$wger
000878602 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bClarivate Analytics Master Journal List$$d2020-01-02
000878602 920__ $$lyes
000878602 9201_ $$0I:(DE-Juel1)IBI-7-20200312$$kIBI-7$$lStrukturbiochemie$$x0
000878602 980__ $$ajournal
000878602 980__ $$aVDB
000878602 980__ $$aI:(DE-Juel1)IBI-7-20200312
000878602 980__ $$aAPC
000878602 980__ $$aUNRESTRICTED
000878602 9801_ $$aAPC
000878602 9801_ $$aFullTexts