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000878656 1001_ $$00000-0002-3969-6821$$ade Jonge, Niels$$b0
000878656 245__ $$aResolution and aberration correction in liquid cell transmission electron microscopy
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000878656 520__ $$aLiquid cell electron microscopy possesses a combination of spatial and temporal resolution that provides a unique view of static structures and dynamic processes in liquids. Optimizing the resolution in liquids requires consideration of both the microscope performance and the properties of the sample. In this Review, we survey the competing factors that determine spatial and temporal resolution for transmission electron microscopy and scanning transmission electron microscopy of liquids. We discuss the effects of sample thickness, stability and dose sensitivity on spatial and temporal resolution. We show that for some liquid samples, spatial resolution can be improved by spherical and chromatic aberration correction. However, other benefits offered by aberration correction may be even more useful for liquid samples. We consider the greater image interpretability offered by spherical aberration correction and the improved dose efficiency for thicker samples offered by chromatic aberration correction. Finally, we discuss the importance of detector and sample parameters for higher resolution in future experiments.
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000878656 7001_ $$0P:(DE-Juel1)130723$$aHouben, Lothar$$b1
000878656 7001_ $$0P:(DE-Juel1)144121$$aDunin-Borkowski, Rafal E.$$b2$$ufzj
000878656 7001_ $$00000-0003-0838-9770$$aRoss, Frances M.$$b3$$eCorresponding author
000878656 773__ $$0PERI:(DE-600)2844635-5$$a10.1038/s41578-018-0071-2$$gVol. 4, no. 1, p. 61 - 78$$n1$$p61 - 78$$tNature reviews Materials$$v4$$x2058-8437$$y2019
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