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@ARTICLE{Haeger:878688,
      author       = {Haeger, Alexa and Costa, Ana S. and Romanzetti, Sandro and
                      Kilders, Axel and Trautwein, Christian and Haberl, Luisa and
                      Beulertz, Michael and Hildebrand, Frank and Schulz, Jörg B.
                      and Reetz, Kathrin},
      title        = {{E}ffect of a multicomponent exercise intervention on brain
                      metabolism: {A} randomized controlled trial on {A}lzheimer's
                      pathology ({D}ementia‐{MOVE})},
      journal      = {Alzheimer's $\&$ dementia / Translational research $\&$
                      clinical interventions Translational research $\&$ clinical
                      interventions},
      volume       = {6},
      number       = {1},
      issn         = {2352-8737},
      address      = {Hoboken, NJ},
      publisher    = {Wiley},
      reportid     = {FZJ-2020-03006},
      pages        = {e12032},
      year         = {2020},
      abstract     = {BackgroundPhysical activity has shown a positive impact on
                      aging and neurodegeneration and represents a possible
                      treatment option in cognitive decline. However, its
                      underlying mechanisms and influences on brain pathology
                      remain unclear. Dementia‐MOVE (Multi‐Objective
                      Validation of Exercise) is a randomized‐controlled pilot
                      trial, including 50 patients with amnestic cognitive
                      impairment associated with Alzheimer's pathology, aiming to
                      analyze the effect of physical activity and fitness on
                      disease progression.MethodsDementia‐MOVE is divided into
                      two arms, of either an intervention comprising physical
                      activity, for at least twice a week, combined with a
                      psychoeducational program, or a sole psychoeducational
                      program. Physical activity intervention includes a
                      supervised and unsupervised multimodal concept combining
                      resistance, endurance, coordinative, and aerobic training.
                      The primary outcome is the change of brain metabolism due to
                      physical interventional treatment. Besides metabolic
                      magnetic resonance imaging (MRI) including sodium and
                      phosphorus imaging, resting state functional MRI, T1‐,
                      T2‐weighted and fluid‐attenuated inversion recovery
                      (FLAIR), as well as diffusion‐weighted imaging (DWI) of
                      the brain and whole‐body fat MRI are performed before and
                      after intervention, and will be compared in their
                      sensitivity for the detection of intervention effects. We
                      further assess cognitive performance, neuropsychiatric
                      symptoms, quality of life, fitness, and sleep via
                      questionnaires/interviews and/or fitness trackers, as well
                      as microbiome, under the aspect of Alzheimer's
                      pathology.DiscussionThe aim of Dementia‐MOVE is to
                      investigate the effect of a multimodal exercise program on
                      Alzheimer's pathology under different aspects of the
                      disease. In this context, one of the main aims is the
                      comparison of different MRI methods regarding their
                      responsiveness for the detection of alterations induced by
                      physical activity. As an underlying goal, new treatment and
                      diagnostic options, as well as the exploration of fitness
                      effects on brain structure and metabolism within a
                      whole‐body perspective of Alzheimer's disease are
                      envisaged.},
      cin          = {JARA-BRAIN / INM-11},
      ddc          = {610},
      cid          = {$I:(DE-82)080010_20140620$ / I:(DE-Juel1)INM-11-20170113},
      pnm          = {573 - Neuroimaging (POF3-573)},
      pid          = {G:(DE-HGF)POF3-573},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:32490142},
      UT           = {WOS:000751652300051},
      doi          = {10.1002/trc2.12032},
      url          = {https://juser.fz-juelich.de/record/878688},
}