000880296 001__ 880296
000880296 005__ 20230207130606.0
000880296 0247_ $$2CORDIS$$aG:(EU-Grant)898059$$d898059
000880296 0247_ $$2CORDIS$$aG:(EU-Call)H2020-MSCA-IF-2019$$dH2020-MSCA-IF-2019
000880296 0247_ $$2originalID$$acorda__h2020::898059
000880296 035__ $$aG:(EU-Grant)898059
000880296 150__ $$aMulti-layered integration of motivated actions and their outcomes in basal ganglia circuits$$y2020-10-01 - 2022-09-30
000880296 371__ $$aACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM$$bAMC$$dNetherlands$$ehttp://www.amc.nl$$vCORDIS
000880296 372__ $$aH2020-MSCA-IF-2019$$s2020-10-01$$t2022-09-30
000880296 450__ $$aGONOGO$$wd$$y2020-10-01 - 2022-09-30
000880296 5101_ $$0I:(DE-588b)5098525-5$$2CORDIS$$aEuropean Union
000880296 680__ $$aWe cross the street when the traffic light is green (action initiation), and we wait if it is red (action suppression), both in order to reach a goal across the street, such as getting an ice cream (rewarding) or insect-repellant to avoid a mosquito bite (aversive). Such action control is dysfunctional in several psychiatric disorders. For example, action initiation and suppression are impaired in patients suffering from depression and impulsivity, respectively. Thus, improving our incomplete understanding of the neural basis of action control has translational value, specifically how action outcome valence (rewarding or aversive) interacts with brain mechanisms of action control (i.e., initiation or suppression). The direct and indirect output pathways of the basal ganglia are strongly implicated in action initiation and suppression, respectively, and receive modulating input from dopamine and serotonin neurons, which are implicated in processing rewarding and aversive stimuli, respectively. I hypothesize that the anatomical and functional integration of these opposing systems supports action control as well as constitutes a neural interface for the interaction of action control and outcome valence. I propose to use a set of innovative and inter-disciplinary approaches that include monitoring neuronal ensemble activity with calcium imaging using implantable, miniaturized fluorescence microscopes and simultaneous optogenetic manipulation in novel transgenic rats performing in a tailor-made behavioral paradigm. I aim to understand the neural mechanisms in the basal ganglia that crucially govern the control over actions with different outcome valences. My anticipated results will inform future research and potentially treatment of psychiatric disorders such as depression and impulsivity disorders. Further, this fellowship will strengthen my position as an independent researcher and increase my chances for a tenure-track position at a European research institution.
000880296 909CO $$ooai:juser.fz-juelich.de:880296$$pauthority$$pauthority:GRANT
000880296 970__ $$aoai:dnet:corda__h2020::16be8a33f9e479658296e941f46986ae
000880296 980__ $$aG
000880296 980__ $$aCORDIS
000880296 980__ $$aAUTHORITY