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001     880296
005     20230207130606.0
024 7 _ |a G:(EU-Grant)898059
|d 898059
|2 CORDIS
024 7 _ |a G:(EU-Call)H2020-MSCA-IF-2019
|d H2020-MSCA-IF-2019
|2 CORDIS
024 7 _ |a corda__h2020::898059
|2 originalID
035 _ _ |a G:(EU-Grant)898059
150 _ _ |a Multi-layered integration of motivated actions and their outcomes in basal ganglia circuits
|y 2020-10-01 - 2022-09-30
371 _ _ |a ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM
|b AMC
|d Netherlands
|e http://www.amc.nl
|v CORDIS
372 _ _ |a H2020-MSCA-IF-2019
|s 2020-10-01
|t 2022-09-30
450 _ _ |a GONOGO
|w d
|y 2020-10-01 - 2022-09-30
510 1 _ |0 I:(DE-588b)5098525-5
|a European Union
|2 CORDIS
680 _ _ |a We cross the street when the traffic light is green (action initiation), and we wait if it is red (action suppression), both in order to reach a goal across the street, such as getting an ice cream (rewarding) or insect-repellant to avoid a mosquito bite (aversive). Such action control is dysfunctional in several psychiatric disorders. For example, action initiation and suppression are impaired in patients suffering from depression and impulsivity, respectively. Thus, improving our incomplete understanding of the neural basis of action control has translational value, specifically how action outcome valence (rewarding or aversive) interacts with brain mechanisms of action control (i.e., initiation or suppression). The direct and indirect output pathways of the basal ganglia are strongly implicated in action initiation and suppression, respectively, and receive modulating input from dopamine and serotonin neurons, which are implicated in processing rewarding and aversive stimuli, respectively. I hypothesize that the anatomical and functional integration of these opposing systems supports action control as well as constitutes a neural interface for the interaction of action control and outcome valence. I propose to use a set of innovative and inter-disciplinary approaches that include monitoring neuronal ensemble activity with calcium imaging using implantable, miniaturized fluorescence microscopes and simultaneous optogenetic manipulation in novel transgenic rats performing in a tailor-made behavioral paradigm. I aim to understand the neural mechanisms in the basal ganglia that crucially govern the control over actions with different outcome valences. My anticipated results will inform future research and potentially treatment of psychiatric disorders such as depression and impulsivity disorders. Further, this fellowship will strengthen my position as an independent researcher and increase my chances for a tenure-track position at a European research institution.
909 C O |o oai:juser.fz-juelich.de:880296
|p authority:GRANT
|p authority
970 _ _ |a oai:dnet:corda__h2020::16be8a33f9e479658296e941f46986ae
980 _ _ |a G
980 _ _ |a CORDIS
980 _ _ |a AUTHORITY

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Marc 21