TY  - JOUR
AU  - Giesen, Kai
AU  - Spahn, Ingo
AU  - Neumaier, Bernd
TI  - Thermochromatographic separation of 45Ti and subsequent radiosynthesis of [45Ti]salan
JO  - Journal of radioanalytical and nuclear chemistry
VL  - 326
SN  - 0022-4081
CY  - Dordrecht [u.a.]
PB  - Springer Science + Business Media B.V
M1  - FZJ-2020-03062
SP  - 1281–1287
PY  - 2020
AB  - Due to its favorable decay properties, the non-standard radionuclide 45Ti is a promising PET isotope for tumor imaging. Additionally, titanium complexes are widely used as anti-tumor agents and 45Ti could be used to study their in vivo distribution and metabolic fate. However, although 45Ti can be obtained using the 45Sc(p,n)45Ti nuclear reaction its facile production is offset by the high oxophilicity and hydrolytic instability of Ti4+ ions in aqueous solutions, which complicate recovery from the irradiated Sc matrix. Most available 45Ti recovery procedures rely on ion exchange chromatography or solvent extraction techniques which are time-consuming, produce large final elution volumes, or, in case of solvent extraction, cannot easily be automated. Thus a more widespread application of 45Ti for PET imaging has been hampered. Here, we describe a novel, solvent-free approach for recovery of 45Ti that involves formation of [45Ti]TiCl4 by heating of an irradiated Sc target in a gas stream of chlorine, followed by thermochromatographic separation of the volatile radiometal chloride from co-produced scandium chloride and trapping of [45Ti]TiCl4 in a glass vial at − 78 °C. The recovery of 45Ti amounted to 76 ± 5% (n = 5) and the radionuclidic purity was determined to be > 99%. After trapping, the [45Ti]TiCl4 could be directly used for 45Ti-radiolabeling, as demonstrated by the successful radiosynthesis of [45Ti][Ti(2,4-salan)].
LB  - PUB:(DE-HGF)16
UR  - <Go to ISI:>//WOS:000578523500022
DO  - DOI:10.1007/s10967-020-07376-2
UR  - https://juser.fz-juelich.de/record/884041
ER  -