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@ARTICLE{Giesen:884041,
      author       = {Giesen, Kai and Spahn, Ingo and Neumaier, Bernd},
      title        = {{T}hermochromatographic separation of 45{T}i and subsequent
                      radiosynthesis of [45{T}i]salan},
      journal      = {Journal of radioanalytical and nuclear chemistry},
      volume       = {326},
      issn         = {0022-4081},
      address      = {Dordrecht [u.a.]},
      publisher    = {Springer Science + Business Media B.V},
      reportid     = {FZJ-2020-03062},
      pages        = {1281–1287},
      year         = {2020},
      abstract     = {Due to its favorable decay properties, the non-standard
                      radionuclide 45Ti is a promising PET isotope for tumor
                      imaging. Additionally, titanium complexes are widely used as
                      anti-tumor agents and 45Ti could be used to study their in
                      vivo distribution and metabolic fate. However, although 45Ti
                      can be obtained using the 45Sc(p,n)45Ti nuclear reaction its
                      facile production is offset by the high oxophilicity and
                      hydrolytic instability of Ti4+ ions in aqueous solutions,
                      which complicate recovery from the irradiated Sc matrix.
                      Most available 45Ti recovery procedures rely on ion exchange
                      chromatography or solvent extraction techniques which are
                      time-consuming, produce large final elution volumes, or, in
                      case of solvent extraction, cannot easily be automated. Thus
                      a more widespread application of 45Ti for PET imaging has
                      been hampered. Here, we describe a novel, solvent-free
                      approach for recovery of 45Ti that involves formation of
                      [45Ti]TiCl4 by heating of an irradiated Sc target in a gas
                      stream of chlorine, followed by thermochromatographic
                      separation of the volatile radiometal chloride from
                      co-produced scandium chloride and trapping of [45Ti]TiCl4 in
                      a glass vial at − 78 °C. The recovery of 45Ti amounted to
                      76 ± $5\%$ (n = 5) and the radionuclidic purity was
                      determined to be $> 99\%.$ After trapping, the [45Ti]TiCl4
                      could be directly used for 45Ti-radiolabeling, as
                      demonstrated by the successful radiosynthesis of
                      [45Ti][Ti(2,4-salan)].},
      cin          = {INM-5},
      ddc          = {540},
      cid          = {I:(DE-Juel1)INM-5-20090406},
      pnm          = {573 - Neuroimaging (POF3-573)},
      pid          = {G:(DE-HGF)POF3-573},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000578523500022},
      doi          = {10.1007/s10967-020-07376-2},
      url          = {https://juser.fz-juelich.de/record/884041},
}