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@ARTICLE{Nechushtai:884078,
      author       = {Nechushtai, Rachel and Karmi, Ola and Zuo, Ke and Marjault,
                      Henri-Baptiste and Darash-Yahana, Merav and Sohn, Yang-Sung
                      and King, Skylar D. and Zandalinas, Sara I. and Carloni,
                      Paolo and Mittler, Ron},
      title        = {{T}he balancing act of {NEET} proteins: {I}ron, {ROS},
                      calcium and metabolism},
      journal      = {Biochimica et biophysica acta / Molecular cell research
                      Molecular cell research},
      volume       = {1867},
      number       = {11},
      issn         = {0167-4889},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier},
      reportid     = {FZJ-2020-03079},
      pages        = {118805 -},
      year         = {2020},
      abstract     = {NEET proteins belong to a highly conserved group of
                      [2Fe–2S] proteins found across all kingdoms of life. Due
                      to their unique [2Fesingle bond2S] cluster structure, they
                      play a key role in the regulation of many different redox
                      and oxidation processes. In eukaryotes, NEET proteins are
                      localized to the mitochondria, endoplasmic reticulum (ER)
                      and the mitochondrial-associated membranes connecting these
                      organelles (MAM), and are involved in the control of
                      multiple processes, ranging from autophagy and apoptosis to
                      ferroptosis, oxidative stress, cell proliferation, redox
                      control and iron and iron‑sulfur homeostasis. Through
                      their different functions and interactions with key proteins
                      such as VDAC and Bcl-2, NEET proteins coordinate different
                      mitochondrial, MAM, ER and cytosolic processes and functions
                      and regulate major signaling molecules such as calcium and
                      reactive oxygen species. Owing to their central role in
                      cells, NEET proteins are associated with numerous human
                      maladies including cancer, metabolic diseases, diabetes,
                      obesity, and neurodegenerative diseases. In recent years, a
                      new and exciting role for NEET proteins was uncovered, i.e.,
                      the regulation of mitochondrial dynamics and morphology.
                      This new role places NEET proteins at the forefront of
                      studies into cancer and different metabolic diseases, both
                      associated with the regulation of mitochondrial dynamics.
                      Here we review recent studies focused on the evolution,
                      biological role, and structure of NEET proteins, as well as
                      discuss different studies conducted on NEET proteins
                      function using transgenic organisms. We further discuss the
                      different strategies used in the development of drugs that
                      target NEET proteins, and link these with the different
                      roles of NEET proteins in cells.},
      cin          = {IAS-5 / INM-9 / GRS},
      ddc          = {570},
      cid          = {I:(DE-Juel1)IAS-5-20120330 / I:(DE-Juel1)INM-9-20140121 /
                      I:(DE-Juel1)GRS-20100316},
      pnm          = {574 - Theory, modelling and simulation (POF3-574)},
      pid          = {G:(DE-HGF)POF3-574},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {32745723},
      UT           = {WOS:000565326000008},
      doi          = {10.1016/j.bbamcr.2020.118805},
      url          = {https://juser.fz-juelich.de/record/884078},
}