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000884241 1001_ $$0P:(DE-HGF)0$$aChernomor, Olga$$b0
000884241 245__ $$aComplex evolution of light-dependent protochlorophyllide oxidoreductases in aerobic anoxygenic phototrophs: origin, phylogeny and function
000884241 260__ $$aOxford$$bOxford Univ. Press$$c2021
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000884241 520__ $$aLight-dependent and dark-operative protochlorophyllide oxidoreductases (LPORs and DPORs) are evolutionary and structurally distinct enzymes that are essential for the synthesis of (bacterio)chlorophyll, the primary pigment needed for both anoxygenic and oxygenic photosynthesis. In contrast to the long-held hypothesis that LPORs are only present in oxygenic phototrophs, we recently identified a functional LPOR in the aerobic anoxygenic phototrophic bacterium (AAPB) Dinoroseobacter shibae, and attributed its presence to a single horizontal gene transfer (HGT) event from cyanobacteria. Here, we provide evidence for the more widespread presence of genuine LPOR enzymes in AAPBs. An exhaustive bioinformatics search identified 36 putative LPORs outside of oxygenic phototrophic bacteria (cyanobacteria) with the majority being AAPBs. Using in vitro and in vivo assays, we show that the large majority of the tested AAPB enzymes are genuine LPORs. Solution structural analyses, performed for two of the AAPB LPORs, revealed a globally conserved structure when compared to a well-characterized cyanobacterial LPOR. Phylogenetic analyses suggest that LPORs were transferred not only from cyanobacteria, but also subsequently between proteobacteria and from proteobacteria to Gemmatimonadetes. Our study thus provides another interesting example for the complex evolutionary processes that govern the evolution of bacteria, involving multiple HGT events that likely occurred at different time points and involved different donors.
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000884241 7001_ $$0P:(DE-Juel1)165808$$aPeters, Lena$$b1
000884241 7001_ $$0P:(DE-Juel1)161384$$aSchneidewind, Judith$$b2
000884241 7001_ $$0P:(DE-Juel1)131500$$aLoeschcke, Anita$$b3
000884241 7001_ $$0P:(DE-Juel1)141796$$aKnieps-Grünhagen, Esther$$b4
000884241 7001_ $$0P:(DE-HGF)0$$aSchmitz, Fabian$$b5
000884241 7001_ $$0P:(DE-Juel1)129081$$avon Lieres, Eric$$b6
000884241 7001_ $$0P:(DE-HGF)0$$aKutta, Roger Jan$$b7
000884241 7001_ $$0P:(DE-HGF)0$$aSvensson, Vera$$b8
000884241 7001_ $$0P:(DE-Juel1)131457$$aJaeger, Karl-Erich$$b9
000884241 7001_ $$0P:(DE-Juel1)131426$$aDrepper, Thomas$$b10
000884241 7001_ $$0P:(DE-HGF)0$$avon Haeseler, Arndt$$b11
000884241 7001_ $$0P:(DE-Juel1)131482$$aKrauss, Ulrich$$b12$$eCorresponding author
000884241 773__ $$0PERI:(DE-600)2024221-9$$a10.1093/molbev/msaa234$$gp. msaa234$$n3$$p819-837$$tMolecular biology and evolution$$v38$$x1537-1719$$y2021
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