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@ARTICLE{Cortese:884701,
      author       = {Cortese, Samuele and Aoki, Yuta Y. and Itahashi, Takashi
                      and Castellanos, F. Xavier and Eickhoff, Simon B.},
      title        = {{S}ystematic {R}eview and {M}eta-analysis: {R}esting
                      {S}tate {F}unctional {M}agnetic {R}esonance {I}maging
                      {S}tudies of {A}ttention-{D}eficit/{H}yperactivity
                      {D}isorder},
      journal      = {Journal of the American Academy of Child and Adolescent
                      Psychiatry},
      volume       = {60},
      number       = {1},
      issn         = {0890-8567},
      address      = {[S.l.]},
      publisher    = {Ovid},
      reportid     = {FZJ-2020-03202},
      pages        = {61-75},
      year         = {2020},
      note         = {This work was partially supported by the Japan Society for
                      the Promotion of Science (JSPS) KAKENHI (grant number
                      18K15493 to Y.Y.A. and 19K03370 and 19H04883 to T.I.), the
                      Takeda Science Foundation (to Y.Y.A.), the SENSHIN Medical
                      Research Foundation (to Y.Y.A.), the Deutsche
                      Forschungsgemeinschaft (DFG, EI 816/11-1), the National
                      Institute of Mental Health (NIMH; R01-MH074457), the
                      Helmholtz Portfolio Theme "Supercomputing and Modeling for
                      the Human Brain" and the European Union’s Horizon 2020
                      Research and Innovation Programme under Grant Agreement
                      785907 (HBP SGA2) (to S.E.), and R61MH113663 (to F.X.C.).},
      abstract     = {ObjectiveWe conducted a meta-analysis of resting state
                      functional magnetic resonance imaging (R-fMRI) studies in
                      children/adolescents and adults with ADHD to assess spatial
                      convergence of findings from available studies.MethodBased
                      on a preregistered protocol in PROSPERO (CRD42019119553), a
                      large set of databases were searched up to April 9th, 2019,
                      with no language/type-of-document restrictions. Study
                      authors were systematically contacted for additional
                      unpublished information/data. R-fMRI studies using
                      seed-based connectivity (SBC) or any other method (non-SBC)
                      reporting whole-brain results of group comparisons between
                      individuals with ADHD and typically developing controls were
                      eligible. Voxel-wise meta-analysis via activation likelihood
                      estimation with cluster-level Family Wise Error (FWE)
                      (voxel-level: p < 0.001; cluster-level: p < 0.05) was used.
                      The full dataset used for analyses will be freely available
                      online in an open source platform
                      (http://anima.fz-juelich.de/).Results30 studies (18 SBC and
                      12 non-SBC), including a total of 1978 participants (1094
                      ADHD; 884 controls) were retained. The meta-analysis focused
                      on SBC studies found no significant spatial convergence of
                      ADHD-related hyper- or hypo-connectivity across studies.
                      This non-significant finding remained after integrating 12
                      non-SBC studies into the main-analysis and in sensitivity
                      analyses limited to studies including only children or only
                      non-medication naïve patients.ConclusionThe lack of
                      significant spatial convergence may be accounted for by
                      heterogeneity in study participants, experimental procedures
                      and analytic flexibility, as well as in ADHD
                      pathophysiology. Alongside other neuroimaging meta-analyses
                      in other psychiatric conditions, our results should inform
                      the conduct and publication of future neuroimaging studies
                      of psychiatric disorders.Key wordsADHDresting
                      stateALEmeta-analysisneuroimaging},
      cin          = {INM-7},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-7-20090406},
      pnm          = {574 - Theory, modelling and simulation (POF3-574) / HBP
                      SGA2 - Human Brain Project Specific Grant Agreement 2
                      (785907) / SMHB - Supercomputing and Modelling for the Human
                      Brain (HGF-SMHB-2013-2017)},
      pid          = {G:(DE-HGF)POF3-574 / G:(EU-Grant)785907 /
                      G:(DE-Juel1)HGF-SMHB-2013-2017},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {32946973},
      UT           = {WOS:000600656300018},
      doi          = {10.1016/j.jaac.2020.08.014},
      url          = {https://juser.fz-juelich.de/record/884701},
}