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@ARTICLE{Wiedenhoeft:884702,
      author       = {Wiedenhoeft, Tabea and Braun, Tobias and Springer, Ronald
                      and Teske, Michael and Noetzel, Erik and Merkel, Rudolf and
                      Csiszar, Agnes},
      title        = {{T}he {B}asement {M}embrane in a 3{D} {B}reast {A}cini
                      {M}odel {M}odulates {D}elivery and {A}nti-{P}roliferative
                      {E}ffects of {L}iposomal {A}nthracyclines},
      journal      = {Pharmaceuticals},
      volume       = {13},
      number       = {9},
      issn         = {1424-8247},
      address      = {Basel},
      publisher    = {MDPI},
      reportid     = {FZJ-2020-03203},
      pages        = {256},
      year         = {2020},
      abstract     = {Breast cancer progression is marked by cancer cell invasion
                      and infiltration, which can be closely linked to sites of
                      tumor-connected basement membrane thinning, lesion, or
                      infiltration. Bad treatment prognosis frequently accompanies
                      lack of markers for targeted therapy, which brings
                      traditional chemotherapy into play, despite its adverse
                      effects like therapy-related toxicities. In the present
                      work, we compared different liposomal formulations for the
                      delivery of two anthracyclines, doxorubicin and
                      aclacinomycin A, to a 2D cell culture and a 3D breast acini
                      model. One formulation was the classical phospholipid
                      liposome with a polyethylene glycol (PEG) layer serving as a
                      stealth coating. The other formulation was fusogenic
                      liposomes, a biocompatible, cationic, three-component system
                      of liposomes able to fuse with the plasma membrane of target
                      cells. For the lysosome entrapment-sensitive doxorubicin,
                      membrane fusion enabled an increased anti-proliferative
                      effect in 2D cell culture by circumventing the endocytic
                      route. In the 3D breast acini model, this process was found
                      to be limited to cells beneath a thinned or compromised
                      basement membrane. In acini with compromised basement
                      membrane, the encapsulation of doxorubicin in fusogenic
                      liposomes increased the anti-proliferative effect of the
                      drug in comparison to a formulation in PEGylated liposomes,
                      while this effect was negligible in the presence of intact
                      basement membranes},
      cin          = {IBI-2},
      ddc          = {610},
      cid          = {I:(DE-Juel1)IBI-2-20200312},
      pnm          = {552 - Engineering Cell Function (POF3-552)},
      pid          = {G:(DE-HGF)POF3-552},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:32961780},
      UT           = {WOS:000580249000001},
      doi          = {10.3390/ph13090256},
      url          = {https://juser.fz-juelich.de/record/884702},
}