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@ARTICLE{Tahmasian:884735,
      author       = {Tahmasian, Masoud and Samea, Fateme and Khazaie, Habibolah
                      and Zarei, Mojtaba and Kharabian, Shahrzad and Hoffstaedter,
                      Felix and Camilleri, Julia A. and Kochunov, Peter and Yeo,
                      B. T. Thomas and Eickhoff, Simon B. and Valk, Sofie},
      title        = {{PHENOTYPIC} {AND} {GENETIC} {CORRELATION} {BETWEEN}
                      {SLEEP}, {BEHAVIOR}, {AND} {MACROSCALE} {CORTICAL} {GREY}
                      {MATTER}},
      reportid     = {FZJ-2020-03229},
      year         = {2019},
      abstract     = {Humans need about 7 to 9 hours of sleep per night. Sleep
                      habits are heritable, associated with brain function and
                      structure, and intrinsically related to well-being, mental
                      and physical health. This raises the question whether
                      associations between sleep, mental and physical health can
                      be attributed to a shared macroscale neurobiology.Combining
                      neuroimaging and behavioral genetic approaches in two
                      independent large-scale datasets (n=1887) we demonstrate
                      phenotypic and genetic correspondence between sleep,
                      intelligence, and BMI. Sleep was associated with local
                      thickness variation in frontal, temporal, and occipital
                      cortices. Using a comprehensive multivariate approach, we
                      identified two robust latent components highlighting the
                      interdigitation of sleep, intelligence, BMI, and depression
                      and their shared relation to regions in unimodal and
                      heteromodal association cortices. Latent relationships were
                      heritable and driven by shared additive genetic factors.
                      These observations provide a system-level perspective on the
                      interrelation of sleep, mental, and physical conditions,
                      anchored in grey-matter neuroanatomy.},
      cin          = {INM-7},
      cid          = {I:(DE-Juel1)INM-7-20090406},
      pnm          = {572 - (Dys-)function and Plasticity (POF3-572)},
      pid          = {G:(DE-HGF)POF3-572},
      typ          = {PUB:(DE-HGF)25},
      doi          = {10.1101/772681},
      url          = {https://juser.fz-juelich.de/record/884735},
}