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@ARTICLE{Chen:884801,
      author       = {Chen, Eunice Y. and Eickhoff, Simon B. and Giovannetti,
                      Tania and Smith, David V.},
      title        = {{O}besity is associated with reduced orbitofrontal cortex
                      volume: {A} coordinate-based meta-analysis},
      journal      = {NeuroImage: Clinical},
      volume       = {28},
      issn         = {2213-1582},
      address      = {[Amsterdam u.a.]},
      publisher    = {Elsevier},
      reportid     = {FZJ-2020-03263},
      pages        = {102420 -},
      year         = {2020},
      abstract     = {Neural models of obesity vary in their focus upon
                      prefrontal and striatal differences. Animal and human
                      studies suggest that differential functioning of the
                      orbitofrontal cortex is associated with obesity. However,
                      meta-analyses of functional neuroimaging studies have not
                      found a clear relationship between the orbitofrontal cortex
                      and obesity. Meta-analyses of structural imaging studies of
                      obesity have shown mixed findings with regards to an
                      association with reduced orbitofrontal cortex gray matter
                      volume. To clarify these findings, we conducted a
                      meta-analysis of 25 voxel-based morphometry studies, and
                      found that greater body mass index is associated with
                      decreased gray matter volume in the right orbitofrontal
                      cortex (Brodmanns’ areas 10 and 11), where family-wise
                      corrected p < .05, N = 7,612. Use of the right orbitofrontal
                      cortex as a seed in a Neurosynth Network Coactivation
                      analysis showed that this region is associated with activity
                      in the left frontal medial cortex, left temporal lobe, right
                      precuneus cortex, posterior division of the left middle
                      temporal gyrus, and right frontal pole. When Neurosynth
                      Network Coactivation results were submitted as regions of
                      interest in the Human Connectome Project data, we found that
                      greater body mass index was associated with greater activity
                      in left frontal medial cortex response to the Gambling Task,
                      where p < .05, although this did not survive
                      Bonferroni-correction. Our findings highlight the importance
                      of the orbitofrontal cortex structure and functioning in
                      neural models of obesity. Exploratory analyses suggest more
                      studies are needed that examine the functional significance
                      of reduced orbitofrontal cortex gray matter volume in
                      obesity, and the effect of age and weight changes on this
                      relationship using longitudinal designs.},
      cin          = {INM-7},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-7-20090406},
      pnm          = {571 - Connectivity and Activity (POF3-571)},
      pid          = {G:(DE-HGF)POF3-571},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {32961404},
      UT           = {WOS:000600619100063},
      doi          = {10.1016/j.nicl.2020.102420},
      url          = {https://juser.fz-juelich.de/record/884801},
}