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@ARTICLE{Pissarek:884816,
      author       = {Pissarek, Margit},
      title        = {{P}ositron {E}mission {T}omography in the {I}nflamed
                      {C}erebellum: {A}ddressing {N}ovel {T}argets among {G}
                      {P}rotein-{C}oupled {R}eceptors and {I}mmune {R}eceptors},
      journal      = {Pharmaceutics},
      volume       = {12},
      number       = {10},
      issn         = {1999-4923},
      address      = {Basel},
      publisher    = {MDPI},
      reportid     = {FZJ-2020-03273},
      pages        = {925 -},
      year         = {2020},
      abstract     = {Inflammatory processes preceding clinical manifestation of
                      brain diseases are moving increasingly into the focus of
                      positron emission tomographic (PET) investigations. A key
                      role in inflammation and as a target of PET imaging efforts
                      is attributed to microglia. Cerebellar microglia, with a
                      predominant ameboid and activated subtype, is of special
                      interest also regarding improved and changing knowledge on
                      functional involvement of the cerebellum in mental
                      activities in addition to its regulatory role in motor
                      function. The present contribution considers small molecule
                      ligands as potential PET tools for the visualization of
                      several receptors recognized to be overexpressed in
                      microglia and which can potentially serve as indicators of
                      inflammatory processes in the cerebellum. The sphingosine 1
                      phosphate receptor 1 (S1P1), neuropeptide Y receptor 2
                      (NPY2) and purinoceptor Y12 (P2Y12) cannabinoid receptors
                      and the chemokine receptor CX3CR1 as G-protein-coupled
                      receptors and the ionotropic purinoceptor P2X7 provide
                      structures with rather classical binding behavior, while the
                      immune receptor for advanced glycation end products (RAGE)
                      and triggering receptor expressed on the triggering receptor
                      expressed on myeloid cells 2 (TREM2) might depend for
                      instance on further accessory proteins. Improvement in
                      differentiation between microglial functional subtypes in
                      comparison to the presently used 18 kDa translocator protein
                      ligands as well as of the knowledge on the role of
                      polymorphisms are special challenges in such developments.},
      cin          = {INM-5},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-5-20090406},
      pnm          = {573 - Neuroimaging (POF3-573)},
      pid          = {G:(DE-HGF)POF3-573},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:32998351},
      UT           = {WOS:000587410200001},
      doi          = {10.3390/pharmaceutics12100925},
      url          = {https://juser.fz-juelich.de/record/884816},
}